Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit
dc.contributor.author | Scott, William L. | |
dc.contributor.author | Zhou, Ziniu | |
dc.contributor.author | Zajdel, Pawel | |
dc.contributor.author | Pawlowski, Maciej | |
dc.contributor.author | O'Donnell, Martin J. | |
dc.contributor.department | Chemistry and Chemical Biology, School of Science | en_US |
dc.date.accessioned | 2019-06-05T20:19:01Z | |
dc.date.available | 2019-06-05T20:19:01Z | |
dc.date.issued | 2010-07-20 | |
dc.description.abstract | Amino acids are Nature's combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-phase synthetic route to large combinatorial variations of this fundamental scaffold, extending the variety of substituted biomimetic molecules available to successfully implement the Distributed Drug Discovery (D3) project. In a single solid-phase sequence, compatible with basic amine substituents, three-point variation is performed at the amino acid a-carbon and the amino and carboxyl functionalities. | en_US |
dc.identifier.citation | Scott, W. L., Zhou, Z., Zajdel, P., Pawłowski, M., & O'Donnell, M. J. (2010). Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit. Molecules (Basel, Switzerland), 15(7), 4961–4983. doi:10.3390/molecules15074961 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/19540 | |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.isversionof | 10.3390/molecules15074961 | en_US |
dc.relation.journal | Molecules | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | PMC | en_US |
dc.subject | Distributed Drug Discovery (D3) | en_US |
dc.subject | Fundamental peptide scaffold | en_US |
dc.subject | Biomimetics | en_US |
dc.subject | Solid-phase organic synthesis | en_US |
dc.subject | Combinatorial chemistry | en_US |
dc.title | Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit | en_US |
dc.type | Article | en_US |