An Analysis of Survival Data when Hazards are not Proportional: Application to a Cancer Treatment Study
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Date
2021-12
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American English
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M.S.
Degree Year
2021
Department
Biostatistics
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Indiana University
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Abstract
The crossing of Kaplan-Meier survival curves presents a challenge when conducting survival analysis studies, making it unclear whether any of the study groups involved present any significant difference in survival. An approach involving the determination of maximum vertical distance between the curves is considered here as a method to assess whether a survival advantage exists between different groups of patients. The method is illustrated on a dataset containing survival times of patients treated with two cancer treatment regimes, one involving treatment by chemotherapy alone, and the other by treatment with both chemotherapy and radiotherapy.
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Indiana University-Purdue University Indianapolis (IUPUI)
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