CAMP: a useful resource for research on antimicrobial peptides

dc.contributor.authorThomas, Shaini
dc.contributor.authorKarnik, Shreyas
dc.contributor.authorBarai, Ram Shankar
dc.contributor.authorJayaraman, V. K.
dc.contributor.authorIdicula-Thomas, Susan
dc.contributor.departmentBioHealth Informatics, School of Informatics and Computingen_US
dc.date.accessioned2020-05-21T20:30:12Z
dc.date.available2020-05-21T20:30:12Z
dc.date.issued2009-11-18
dc.description.abstractAntimicrobial peptides (AMPs) are gaining popularity as better substitute to antibiotics. These peptides are shown to be active against several bacteria, fungi, viruses, protozoa and cancerous cells. Understanding the role of primary structure of AMPs in their specificity and activity is essential for their rational design as drugs. Collection of Anti-Microbial Peptides (CAMP) is a free online database that has been developed for advancement of the present understanding on antimicrobial peptides. It is manually curated and currently holds 3782 antimicrobial sequences. These sequences are divided into experimentally validated (patents and non-patents: 2766) and predicted (1016) datasets based on their reference literature. Information like source organism, activity (MIC values), reference literature, target and non-target organisms of AMPs are captured in the database. The experimentally validated dataset has been further used to develop prediction tools for AMPs based on the machine learning algorithms like Random Forests (RF), Support Vector Machines (SVM) and Discriminant Analysis (DA). The prediction models gave accuracies of 93.2% (RF), 91.5% (SVM) and 87.5% (DA) on the test datasets. The prediction and sequence analysis tools, including BLAST, are integrated in the database. CAMP will be a useful database for study of sequence-activity and -specificity relationships in AMPs. CAMP is freely available at http://www.bicnirrh.res.in/antimicrobial.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationShaini Thomas, Shreyas Karnik, Ram Shankar Barai, V. K. Jayaraman, Susan Idicula-Thomas, CAMP: a useful resource for research on antimicrobial peptides, Nucleic Acids Research, Volume 38, Issue suppl_1, 1 January 2010, Pages D774–D780, https://doi.org/10.1093/nar/gkp1021en_US
dc.identifier.urihttps://hdl.handle.net/1805/22859
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionof10.1093/nar/gkp1021en_US
dc.relation.journalNucleic Acids Researchen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourcePublisheren_US
dc.subjectAntimicrobial peptidesen_US
dc.subjectCollection of Anti-Microbial Peptides (CAMP)en_US
dc.subjectFree online databaseen_US
dc.subjectMachine learning algorithmsen_US
dc.titleCAMP: a useful resource for research on antimicrobial peptidesen_US
dc.typeArticleen_US
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