Cholestasis in the First Trimester Associated with Rare ABCG5/8 Variants: A Case Study

dc.contributor.authorGanapaneni, Sruthi
dc.contributor.authorArul Dhas, Blessed Winston
dc.contributor.authorVuppalanchi, Raj
dc.contributor.authorQuinney, Sara
dc.date.accessioned2024-09-18T20:26:35Z
dc.date.available2024-09-18T20:26:35Z
dc.date.issued2022-07-28
dc.description.abstractCholestasis in the First Trimester Associated with Rare ABCG5/8 Variants: A Case Study Sruthi Ganapaneni 1, Blessed Winston Arul Dhas 2, Raj Vuppalanchi 2, Sara Quinney 2,3 1 Indiana University School of Medicine; 2 Indiana University School of Medicine, Department of Medicine; 3 Indiana University School of Medicine, Department of Obstetrics and Gynecology Purpose/Background: Obstetric cholestasis, or intrahepatic cholestasis of pregnancy (ICP), is a liver disease that usually presents in the third trimester of pregnancy. It is characterized by pruritis that is associated with elevated liver enzymes and bile acids. This condition can have potentially serious effects on the fetus due to the buildup of serum bile acids resulting from the obstruction of bile flow. Methods/Case Overview: A 28-year-old patient, who was pregnant for the third time, developed pruritis in the first trimester and presented with blood work that showed elevated total bile acids and liver enzymes. A medical history revealed similar symptoms amongst her female relatives during their pregnancies as well as the patient’s own previous pregnancies, suggesting a genetic component in the etiology of the disease. Genetic testing supported this hypothesis and showed variants of unknown significance that indicated a duplication in the ABCG5 and ABCDG8 genes. Results/Discussion: This finding was rather unusual as these genes have not yet been clinically associated with ICP. The ABCG5 and ABCG8 genes code for canicular bile transporters in the liver that transport cholesterol into the bile. Overexpression of these transporters due to the duplication in her genes may result in increased transport of cholesterol into bile, disrupting the regular composition of bile. The resulting increased bile viscosity may cause bile stasis or blockage, and this proposed mechanism can possibly explain the pathophysiology behind this unusual case of cholestasis. Conclusion and Potential Impact: ICP can have potential serious effects on the developing fetus, and its etiology is still being understood. The novel ABCG5/8 gene duplication is a novel variant that may lead to earlier onset of ICP than commonly known variants.
dc.identifier.citationGanapaneni S., Arul Dhas BW., Vuppalanchi R., Quinney S. (2023). Cholestasis in the First Trimester Associated with Rare ABCG5/8 Variants: A Case Study. Poster presented at: IMPRS Research Symposium; July 2022; Indianapolis IN Ganapaneni S., Arul Dhas BW., Vuppalanchi R., Quinney S. (2023). Cholestasis in the First Trimester Associated with Rare ABCG5/8 Variants: A Case Study. Poster presented at IUSM Medical and Molecular Genetics Department Symposium; September 2023; Indianapolis IN Ganapaneni S., Arul Dhas BW., Vuppalanchi R., Quinney S. (2023). Cholestasis in the First Trimester Associated with Rare ABCG5/8 Variants: A Case Study. Poster presented at IUSM Education Day; April 2024; Indianapolis IN
dc.identifier.urihttps://hdl.handle.net/1805/43416
dc.language.isoen_US
dc.subjectCholestasis
dc.subjectICP
dc.subjectIntrahepatic Cholestasis of Pregnancy
dc.subjectABCG5
dc.subjectABCG8
dc.subjectgenetics
dc.subjectvariants of unknown signficance
dc.titleCholestasis in the First Trimester Associated with Rare ABCG5/8 Variants: A Case Study
dc.typePoster
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