Effects of Soy Peptide on Dendritic Cells

dc.contributor.authorShipman, Kaylee
dc.contributor.authorTung, Chun-Yu
dc.contributor.authorHan, Ling
dc.contributor.authorPatel, Amy
dc.contributor.authorCorn, Caleb
dc.contributor.authorChang, Hua-Chen
dc.date.accessioned2015-09-08T18:24:56Z
dc.date.available2015-09-08T18:24:56Z
dc.date.issued2013-04-05
dc.descriptionposter abstracten_US
dc.description.abstractInnate immunity is mediated by effector cells, including NK cells, dendritic cells (DCs), macrophages, and polymorphonuclear phagocytes, which can respond immediately after activation through receptors encoded by germ-line genes. Innate immune responses represent the first line of defense in immunosurveillance. Interventions that enhance the functions of innate immunity will be an important armamentarium to human health. We recently exploited a natural dietary soy peptide called lunasin to improve the immune functions. The hypothesis was that lunasin peptide has stimulatory effects on immune cells. To test this hypothesis, human peripheral blood mononuclear cells (PBMCs) of healthy donors were stimulated with or without lunasin. We found that lunasin is capable of stimulating DCs to up-regulate chemokines (CCL2, CCL3, and CCL4), cytokines (TNFα and IFNα), and co-stimulatory molecules (CD80, CD86). In addition, lunasin-treated DCs can provide NK with required signals for activation. Taken together, our results support the immunomodulatory activity of soy peptide on DCs, which leads to enhancement of innate immunity.en_US
dc.identifier.citationShipman, Kaylee, Chun-Yu Tung, Ling Han, Amy Patel, Caleb Corn, and Hua-Chen Chang. (2013, April 5). Effects of Soy Peptide on Dendritic Cells. Poster session presented at IUPUI Research Day 2013, Indianapolis, Indiana.en_US
dc.identifier.urihttps://hdl.handle.net/1805/6786
dc.language.isoen_USen_US
dc.publisherOffice of the Vice Chancellor for Researchen_US
dc.subjectInnate immunityen_US
dc.subjecteffector cellsen_US
dc.subjectNK cellsen_US
dc.subjectdendritic cells (DCs)en_US
dc.subjectmacrophagesen_US
dc.subjectpolymorphonuclear phagocytesen_US
dc.subjectgerm-line genesen_US
dc.subjectimmunosurveillanceen_US
dc.titleEffects of Soy Peptide on Dendritic Cellsen_US
dc.typePresentationen_US
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