Hydrogen sulfide therapy improves intestinal recovery through endothelial nitric oxide dependent mechanisms
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Date
2017
Authors
Language
American English
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Degree
M.S.
Degree Year
2018
Department
Translational Science
Grantor
Indiana University
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Abstract
H2S is a gaseous mediator that acts as an anti-inflammatory agent contributing to gastrointestinal mucosal defense. It promotes vascular dilation, mucosal repair, and resolution of inflammation following intestinal ischemia and may be exploited as a novel therapeutic agent. It is unclear if H2S works through nitric oxide-dependent pathways in the intestine. We appreciated that H2S was able to improve post-ischemic recovery of mesenteric perfusion, mucosal integrity, and inflammation. The beneficial effects of H2S appear to be mediated through endothelial nitric oxide-dependent pathways.
Description
Indiana University Purdue University Indianapolis
