A comparison of IgA antibody levels in caries-resistant and caries-susceptible children

dc.contributor.advisorHughes, Christopher V.
dc.contributor.authorRose, Paul Todden_US
dc.contributor.otherAvery, David R.
dc.contributor.otherSanders, Brian J.
dc.contributor.otherBranca, Ronald A.
dc.contributor.otherGregory, Richard L.
dc.date.accessioned2014-04-24T19:36:49Z
dc.date.available2014-04-24T19:36:49Z
dc.date.issued1993
dc.degree.date1993en_US
dc.degree.disciplineSchool of Dentistryen_US
dc.degree.grantorIndiana Universityen_US
dc.degree.levelM.S.D.en_US
dc.descriptionIndiana University-Purdue University Indianapolis (IUPUI)en_US
dc.description.abstractSecretory immunity is believed to play a role in natural resistance to dental caries. Although dental caries has dramatically decreased in children in the United States, there remains a population of caries-susceptible children even in fluoridated communities. Previous studies have shown a positive correlation between salivary immunoglobulin A (sIgA) antibody levels to Streptococcus mutans and caries resistance in adults. In the present study, an enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels to S. mutans in saliva from 20 caries susceptible (DMFS greater than 5) and 20 caries-resistant (DMFS less than or equal to 1) children (ages 7-11). All subjects resided in fluoridated communities. Salivary S. mutans numbers were significantly higher (p ≤ 0.05) in the caries susceptible (31.2 percent of total streptococci) group than in the caries resistant (1.6 percent of total streptococci) group. Whole saliva from caries-resistant children had significantly higher (p = 0.05) levels of IgA antibodies to S. mutans than saliva from caries-susceptible children. However, whole saliva from caries-resistant children had similar levels of IgA1 or IgA2 antibodies against S. mutans to saliva from caries-susceptible children. These results suggest that IgA antibody to S. mutans may play a role in natural protection from dental caries in children and confirm previous reports indicating a role for salivary IgA antibodies to S. mutans in mediation of caries.en_US
dc.identifier.urihttps://hdl.handle.net/1805/4377
dc.identifier.urihttp://dx.doi.org/10.7912/C2/1626
dc.language.isoen_USen_US
dc.subject.meshDental Caries -- in infancy and childhooden_US
dc.subject.meshImmunoglobulin Aen_US
dc.subject.meshSalivaen_US
dc.subject.meshStreptococcus mutansen_US
dc.titleA comparison of IgA antibody levels in caries-resistant and caries-susceptible childrenen_US
dc.typeThesisen
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