A comparison of IgA antibody levels in caries-resistant and caries-susceptible children
dc.contributor.advisor | Hughes, Christopher V. | |
dc.contributor.author | Rose, Paul Todd | en_US |
dc.contributor.other | Avery, David R. | |
dc.contributor.other | Sanders, Brian J. | |
dc.contributor.other | Branca, Ronald A. | |
dc.contributor.other | Gregory, Richard L. | |
dc.date.accessioned | 2014-04-24T19:36:49Z | |
dc.date.available | 2014-04-24T19:36:49Z | |
dc.date.issued | 1993 | |
dc.degree.date | 1993 | en_US |
dc.degree.discipline | School of Dentistry | en_US |
dc.degree.grantor | Indiana University | en_US |
dc.degree.level | M.S.D. | en_US |
dc.description | Indiana University-Purdue University Indianapolis (IUPUI) | en_US |
dc.description.abstract | Secretory immunity is believed to play a role in natural resistance to dental caries. Although dental caries has dramatically decreased in children in the United States, there remains a population of caries-susceptible children even in fluoridated communities. Previous studies have shown a positive correlation between salivary immunoglobulin A (sIgA) antibody levels to Streptococcus mutans and caries resistance in adults. In the present study, an enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels to S. mutans in saliva from 20 caries susceptible (DMFS greater than 5) and 20 caries-resistant (DMFS less than or equal to 1) children (ages 7-11). All subjects resided in fluoridated communities. Salivary S. mutans numbers were significantly higher (p ≤ 0.05) in the caries susceptible (31.2 percent of total streptococci) group than in the caries resistant (1.6 percent of total streptococci) group. Whole saliva from caries-resistant children had significantly higher (p = 0.05) levels of IgA antibodies to S. mutans than saliva from caries-susceptible children. However, whole saliva from caries-resistant children had similar levels of IgA1 or IgA2 antibodies against S. mutans to saliva from caries-susceptible children. These results suggest that IgA antibody to S. mutans may play a role in natural protection from dental caries in children and confirm previous reports indicating a role for salivary IgA antibodies to S. mutans in mediation of caries. | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/4377 | |
dc.identifier.uri | http://dx.doi.org/10.7912/C2/1626 | |
dc.language.iso | en_US | en_US |
dc.subject.mesh | Dental Caries -- in infancy and childhood | en_US |
dc.subject.mesh | Immunoglobulin A | en_US |
dc.subject.mesh | Saliva | en_US |
dc.subject.mesh | Streptococcus mutans | en_US |
dc.title | A comparison of IgA antibody levels in caries-resistant and caries-susceptible children | en_US |
dc.type | Thesis | en |