Mechanisms of alcohol-induced damage to the developing nervous system

dc.contributor.authorGoodlett, Charles R.
dc.contributor.authorHorn, Kristin H.
dc.contributor.departmentPsychology, School of Scienceen_US
dc.date.accessioned2019-10-23T19:27:25Z
dc.date.available2019-10-23T19:27:25Z
dc.date.issued2001
dc.description.abstractNumerous mechanisms likely contribute to the damaging effects of prenatal alcohol exposure on the developing fetus and particularly the developing central nervous system (CNS). The coexistence of a multitude of mechanisms that may act simultaneously or consecutively and differ among various cell types poses particular challenges to researchers. To study alcohol’s effects on the fetus more easily, investigators have used animal models and tissue-culture experiments. Such approaches have identified numerous potential mechanisms through which alcohol acts on the fetus, many of which result in cell death by necrosis or apoptosis. Among these mechanisms are increased oxidative stress, damage to the mitochondria, interference with the activity of growth factors, effects on glia cells, impaired development and function of chemical messenger systems involved in neuronal communication, changes in the transport and uptake of the sugar glucose, effects on cell adhesion, and changes in the regulation of gene activity during development.en_US
dc.identifier.citationGoodlett, C. R., & Horn, K. H. (2001). Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 25(3), 175–184.en_US
dc.identifier.urihttps://hdl.handle.net/1805/21238
dc.language.isoen_USen_US
dc.publisherThe National Institute on Alcohol Abuse and Alcoholismen_US
dc.relation.journalAlcohol Research & Healthen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectPrenatal alcohol exposureen_US
dc.subjectCentral nervous systemen_US
dc.subjectOxidative stressen_US
dc.subjectMitochondriaen_US
dc.subjectGrowth-arresting factorsen_US
dc.subjectEmbryologic developmenten_US
dc.subjectAlcohol-related intrauterine disorderen_US
dc.subjectAlcohol-related neurodevelopmental disorderen_US
dc.subjectNecrosisen_US
dc.subjectNeurotransmittersen_US
dc.subjectGlucose intoleranceen_US
dc.subjectCell adhesion moleculesen_US
dc.titleMechanisms of alcohol-induced damage to the developing nervous systemen_US
dc.typeArticleen_US
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