Browsing by Subject "synthesis"

Now showing 1 - 2 of 2
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    Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives
    (Elsevier, 2018) Wang, Hongjian; Lv, Kai; Li, Xiaoning; Wang, Bo; Wang, Apeng; Tao, Zeyu; Geng, Yunhe; Wang, Bin; Huang, Menghao; Liu, Mingliang; Guo, Huiyuan; Lu, Yu; Medicine, School of Medicine
    We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N-(pyridine-2-yl)methyl 3,5-dinitrobenzamides A6, A11, C1 and C4 have not only the same excellent MIC values of <0.016 μg/mL against both drug-sensitive MTB strain H37Rv and two drug-resistant clinical isolates as PBTZ169 and the lead 1, but also acceptable safety indices (SI > 1500), opening a new direction for further development.
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    Researching Feedback: Mixed-Methods Research
    (Wiley, 2024) Ene, Estela; English, School of Liberal Arts
    Mixed-methods research are sometimes used to explore feedback effectiveness, though not nearly as much as quantitative methods. Mixed methods help expand the array of topics and perspectives explored. Generalizability continues to be a weakness of mixed-methods research.