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Browsing by Subject "salts"

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    Amide Synthesis through the In Situ Generation of Chloro- and Imido-Phosphonium Salts
    (ACS, 2020-06) Irving, Charles D.; Floreancig, Jack T.; Laulhé, Sébastien; Chemistry and Chemical Biology, School of Science
    We describe a methodology for the amidation of carboxylic acids by generating phosphonium salts in situ from N-chlorophthalimide and triphenylphosphine. Aliphatic, benzylic, and aromatic carboxylic acids can be transformed into their amide counter parts using primary and secondary amines. This functional group interconversion is achieved at room temperature in good to excellent yields. Mechanistic work shows the in situ formation of chloro- and imido-phosphonium salts that react as activating agents for carboxylic acids and generate an acyloxy-phosphonium species.
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