Browsing by Subject "proteoforms"

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    TopPIC: a software tool for top-down mass spectrometry-based proteoform identification and characterization
    (Oxford University Press, 2016-11-15) Kou, Qiang; Xun, Likun; Liu, Xiaowen; BioHealth Informatics, School of Informatics and Computing
    Summary: Top-down mass spectrometry enables the observation of whole complex proteoforms in biological samples and provides crucial information complementary to bottom-up mass spectrometry. Because of the complexity of top-down mass spectra and proteoforms, it is a challenging problem to efficiently interpret top-down tandem mass spectra in high-throughput proteome-level proteomics studies. We present TopPIC, a tool that efficiently identifies and characterizes complex proteoforms with unknown primary structure alterations, such as amino acid mutations and post-translational modifications, by searching top-down tandem mass spectra against a protein database., Availability and Implementation: http://proteomics.informatics.iupui.edu/software/toppic/, Contact: xwliu@iupui.edu, Supplementary information: Supplementary data are available at Bioinformatics online.