Browsing by Subject "polyethylene terephthalate"

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    Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration
    (IMR Press, 2022-06-09) Choe, H.; Hausman, B. S.; Hujer, K. M.; Akkus, O.; Rather, P. N.; Lee, Z.; Bonomo, R.A.; Greenfield, E. M.; Orthopaedic Surgery, School of Medicine
    Implant infection impairs osseointegration of orthopaedic implants by inducing inflammation. Acinetobacter spp. are increasingly prevalent multi-drug resistant bacteria that can cause osteomyelitis. Acinetobacter spp. can also cause inflammation and thereby inhibit osseointegration in mice. The purpose of the present study was to investigate the role of quorum sensing in this context. Therefore, wild-type bacteria were compared with an isogenic abaI mutant defective in quorum sensing in a murine osseointegration model. The abaI quorum- sensing mutant affected significantly less osseointegration and interleukin (IL) 1β levels, without detectably altering other pro-inflammatory cytokines. Wild-type bacteria had fewer effects on IL1 receptor (IL1R)−/− mice. These results indicated that quorum sensing in Acinetobacter spp. contributed to IL1β induction and the resultant inhibition of osseointegration in mice. Moreover, targeting the Gram-negative acyl-homoserine lactone quorum sensing may be particularly effective for patients with Acinetobacter spp. infections.
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    Semi-transparent reduced graphene oxide photodetectors for ultra-low power operation
    (Optica, 2021) Tu, Wei-Chen; Shih, Yi-Hsiang; Huang, Jing-Hong; Chen, Yu-Cheng; Biostatistics, School of Public Health
    The emerged demand for high-performance systems promotes the development of two-dimensional (2D) graphene-based photodetectors. However, these graphene-based photodetectors are usually fabricated by an expensive photolithography and complicated transferred process. Here, a semi-transparent reduced graphene oxide (rGO) photodetector on a polyethylene terephthalate (PET) substrate with ultra-low power operation by simple processes is developed. The photodetector has achieved a transmittance about 60%, a superior responsivity of 375 mA/W and a high detectivity of 1012 Jones at a bias of -1.5 V. Even the photodetector is worked at zero bias, the photodetector exhibits a superior on/off ratio of 12. Moreover, the photoresponse of such photodetector displays little reduction after hundred times bending, revealing that the photodetector is reliable and robust. The proposed fabrication strategy of the photodetector will be beneficial to the integration of semi-transparent and low-power wearable devices in the future.