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Item Comparison of Supervised Machine Learning and Probabilistic Approaches for Record Linkage(AMIA Informatics summit 2019 Conference Proceedings., 2020-03-25) McNutt, Andrew T.; Grannis, Shaun J.; Bo, Na; Xu, Huiping; Kasthurirathne, Suranga N.Record linkage is vital to prevent fragmentation of patient data. Machine learning approaches present considerable potential for record linkage. We compared the performance of three machine learning algorithms to an established probabilistic record linkage technique. Machine learning approaches exhibited results that were comparable, or statistically superior to the established probabilistic approach. It is unclear if the cost of manually reviewing datasets for supervised learning is justified by the performance improvements they yield.Item Evaluating the effect of data standardization and validation on patient matching accuracy(Oxford, 2019-05) Grannis, Shaun; Xu, Huiping; Vest, Josh; Kasthurirathne, Suranga; Bo, Na; Moscovitch, Ben; Torkzadeh, Rita; Rising, Josh; Family Medicine, School of MedicineObjective This study evaluated the degree to which recommendations for demographic data standardization improve patient matching accuracy using real-world datasets. Materials and Methods We used 4 manually reviewed datasets, containing a random selection of matches and nonmatches. Matching datasets included health information exchange (HIE) records, public health registry records, Social Security Death Master File records, and newborn screening records. Standardized fields including last name, telephone number, social security number, date of birth, and address. Matching performance was evaluated using 4 metrics: sensitivity, specificity, positive predictive value, and accuracy. Results Standardizing address was independently associated with improved matching sensitivities for both the public health and HIE datasets of approximately 0.6% and 4.5%. Overall accuracy was unchanged for both datasets due to reduced match specificity. We observed no similar impact for address standardization in the death master file dataset. Standardizing last name yielded improved matching sensitivity of 0.6% for the HIE dataset, while overall accuracy remained the same due to a decrease in match specificity. We noted no similar impact for other datasets. Standardizing other individual fields (telephone, date of birth, or social security number) showed no matching improvements. As standardizing address and last name improved matching sensitivity, we examined the combined effect of address and last name standardization, which showed that standardization improved sensitivity from 81.3% to 91.6% for the HIE dataset. Conclusions Data standardization can improve match rates, thus ensuring that patients and clinicians have better data on which to make decisions to enhance care quality and safety.Item Score Test for Assessing the Conditional Dependence in Latent Class Models and its Application to Record Linkage(Oxford, 2022-11) Xu, Huiping; Li, Xiaochun; Zhang, Zuoyi; Grannis, Shaun; Biostatistics and Health Data Science, School of MedicineThe Fellegi–Sunter model has been widely used in probabilistic record linkage despite its often invalid conditional independence assumption. Prior research has demonstrated that conditional dependence latent class models yield improved match performance when using the correct conditional dependence structure. With a misspecified conditional dependence structure, these models can yield worse performance. It is, therefore, critically important to correctly identify the conditional dependence structure. Existing methods for identifying the conditional dependence structure include the correlation residual plot, the log-odds ratio check, and the bivariate residual, all of which have been shown to perform inadequately. Bootstrap bivariate residual approach and score test have also been proposed and found to have better performance, with the score test having greater power and lower computational burden. In this paper, we extend the score-test-based approach to account for different conditional dependence structures. Through a simulation study, we develop practical recommendations on the utilisation of the score test and assess the match performance with conditional dependence identified by the proposed method. Performance of the proposed method is further evaluated using a real-world record linkage example. Findings show that the proposed method leads to improved matching accuracy relative to the Fellegi–Sunter model.