Browsing by Subject "particle swarm optimization"

Now showing 1 - 7 of 7
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    Application of quantitative analysis in treatment of osteoporosis and osteoarthritis
    (2013-11-08) Chen, Andy Bowei; Yokota, Hiroki, 1955-; Na, Sungsoo; Schild, John H.
    As our population ages, treating bone and joint ailments is becoming increasingly important. Both osteoporosis, a bone disease characterized by a decreased density of mineral in bone, and osteoarthritis, a joint disease characterized by the degeneration of cartilage on the ends of bones, are major causes of decreased movement ability and increased pain. To combat these diseases, many treatments are offered, including drugs and exercise, and much biomedical research is being conducted. However, how can we get the most out of the research we perform and the treatment we do have? One approach is through computational analysis and mathematical modeling. In this thesis, quantitative methods of analysis are applied in different ways to two systems: osteoporosis and osteoarthritis. A mouse model simulating osteoporosis is treated with salubrinal and knee loading. The bone and cell data is used to formulate a system of differential equations to model the response of bone to each treatment. Using Particle Swarm Optimization, optimal treatment regimens are found, including a consideration of budgetary constraints. Additionally, an in vitro model of osteoarthritis in chondrocytes receives RNA silencing of Lrp5. Microarray analysis of gene expression is used to further elucidate the mode of regulation of ADAMTS5, an aggrecanase associated with cartilage degradation, by Lrp5, including the development of a mathematical model. The math model of osteoporosis reveals a quick response to salubrinal and a delayed but substantial response to knee loading. Consideration of cost effectiveness showed that as budgetary constraints increased, treatment did not start until later. The quantitative analysis of ADAMTS5 regulation suggested the involvement of IL1B and p38 MAPK. This research demonstrates the application of quantitative methods to further the usefulness of biomedical and biomolecular research into treatment and signaling pathways. Further work using these techniques can help uncover a bigger picture of osteoarthritis's mode of action and ideal treatment regimens for osteoporosis.
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    Electronic warfare asset allocation with human-swarm interaction
    (2018-05) Boler, William M.; Christopher, Lauren; King, Brian; Salama, Paul
    Finding the optimal placement of receiving assets among transmitting targets in a three-dimensional (3D) space is a complex and dynamic problem that is solved in this work. The placement of assets in R^6 to optimize the best coverage of transmitting targets requires the placement in 3D-spatiality, center frequency assignment, and antenna azimuth and elevation orientation, with respect to power coverage at the receiver without overloading the feed-horn, maintaining suficient power sensitivity levels, and maintaining terrain constraints. Further complexities result from the human-user having necessary and time-constrained knowledge to real-world conditions unknown to the problem space, such as enemy positions or special targets, resulting in the requirement of the user to interact with the solution convergence in some fashion. Particle Swarm Optimization (PSO) approaches this problem with accurate and rapid approximation to the electronic warfare asset allocation problem (EWAAP) with near-real-time solution convergence using a linear combination of weighted components for tness comparison and particles representative of asset con- gurations. Finally, optimizing the weights for the tness function requires the use of unsupervised machine learning techniques to reduce the complexity of assigning a tness function using a Meta-PSO. The result of this work implements a more realistic asset allocation problem with directional antenna and complex terrain constraints that is able to converge on a solution on average in 488.7167+-15.6580 ms and has a standard deviation of 15.3901 for asset positions across solutions.
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    Global Nonlinear Kernel Prediction for Large Dataset with a Particle Swarm Optimized Interval Support Vector Regression
    (IEEE, 2015-10) Ding, Yongsheng; Cheng, Lijun; Pedrycz, Witold; Hao, Kuangrong; Department of Medical and Molecular Genetics, IU School of Medicine
    A new global nonlinear predictor with a particle swarm-optimized interval support vector regression (PSO-ISVR) is proposed to address three issues (viz., kernel selection, model optimization, kernel method speed) encountered when applying SVR in the presence of large data sets. The novel prediction model can reduce the SVR computing overhead by dividing input space and adaptively selecting the optimized kernel functions to obtain optimal SVR parameter by PSO. To quantify the quality of the predictor, its generalization performance and execution speed are investigated based on statistical learning theory. In addition, experiments using synthetic data as well as the stock volume weighted average price are reported to demonstrate the effectiveness of the developed models. The experimental results show that the proposed PSO-ISVR predictor can improve the computational efficiency and the overall prediction accuracy compared with the results produced by the SVR and other regression methods. The proposed PSO-ISVR provides an important tool for nonlinear regression analysis of big data.
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    Human Fitness Functions
    (IEEE, 2015-09) Christopher, Lauren; Reynolds, Joshua; Crespo, Jonah; Eberhart, Russ; Shaffer, Patrick; Department of Electrical and Computer Engineering, School of Engineering and Technology
    "Be careful what you measure" is a management adage that applies to Particle Swarm Optimization (PSO) and is especially important with Humans in the Swarm. PSO has been applied to the autonomous asset management problem in electronic warfare where the speed provides fast optimization of frequency allocations for receivers and jammers in highly complex and dynamic environments in our previous work. In this optimization problem, one key part of the fitness is adapted by the human: the 2D (and future 3D) battlefield environment. This paper explores the use of the human in the fitness function, adapting to the battlefield conditions as the PSO is acting. Two aspects of dynamic human influence will be discussed: Simple geometric zones and pheromone influenced zones.
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    Modified Particle Swarm Optimization Based Powertrain Energy Management for Range Extended Electric Vehicle
    (MDPI, 2023-06-30) Parkar, Omkar; Snyder, Benjamin; Rahi, Adibuzzaman; Anwar, Sohel; Mechanical and Energy Engineering, School of Engineering and Technology
    The efficiency of hybrid electric powertrains is heavily dependent on energy and power management strategies, which are sensitive to the dynamics of the powertrain components that they use. In this study, a Modified Particle Swarm Optimization (Modified PSO) methodology, which incorporates novel concepts such as the Vector Particle concept and the Seeded Particle concept, has been developed to minimize the fuel consumption and NOx emissions for an extended-range electric vehicle (EREV). An optimization problem is formulated such that the battery state of charge (SOC) trajectory over the entire driving cycle, a vector of size 50, is to be optimized via a control lever consisting of 50 engine/generator speed points spread over the same 2 h cycle. Thus, the vector particle consisted of the battery SOC trajectory, having 50 elements, and 50 engine/generator speed points, resulting in a 100-D optimization problem. To improve the convergence of the vector particle PSO, the concept of seeding the vector particles was introduced. Additionally, further improvements were accomplished by adapting the Time-Varying Acceleration Coefficients (TVAC) PSO and Frankenstein’s PSO features to the vector particles. The MATLAB/SIMULINK platform was used to validate the developed commercial vehicle hybrid powertrain model against a similar ADVISOR powertrain model using a standard rule-based PMS algorithm. The validated model was then used for the simulation of the developed, modified PSO algorithms through a multi-objective optimization strategy using a weighted sum fitness function. Simulation results show that a fuel consumption reduction of 12% and a NOx emission reduction of 35% were achieved individually by deploying the developed algorithms. When the multi-objective optimization was applied, a simultaneous reduction of 9.4% fuel consumption and 7.9% NOx emission was achieved when compared to the baseline model with the rule-based PMS algorithm.
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    Real-Time State-of-Charge Estimation via Particle Swarm Optimization on a Lithium-Ion Electrochemical Cell Model
    (MDPI, 2019-01) Chandra Shekar, Arun; Anwar, Sohel; Mechanical and Energy Engineering, School of Engineering and Technology
    With the ever-increasing usage of lithium-ion batteries, especially in transportation applications, accurate estimation of battery state of charge (SOC) is of paramount importance. A majority of the current SOC estimation methods rely on data collected and calibrated offline, which could lead to inaccuracies in SOC estimation under different operating conditions or when the battery ages. This paper presents a novel real-time SOC estimation of a lithium-ion battery by applying the particle swarm optimization (PSO) method to a detailed electrochemical model of a single cell. This work also optimizes both the single-cell model and PSO algorithm so that the developed algorithm can run on an embedded hardware with reasonable utilization of central processing unit (CPU) and memory resources while estimating the SOC with reasonable accuracy. A modular single-cell electrochemical model, as well as the proposed constrained PSO-based SOC estimation algorithm, was developed in Simulink©, and its performance was theoretically verified in simulation. Experimental data were collected for healthy and aged Li-ion battery cells in order to validate the proposed algorithm. Both simulation and experimental results demonstrate that the developed algorithm is able to accurately estimate the battery SOC for 1C charge and 1C discharge operations for both healthy and aged cells. View Full-Text
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    Statistical identifiability and convergence evaluation for nonlinear pharmacokinetic models with particle swarm optimization
    (Elsevier, 2014-02) Kim, Seongho; Li, Lang; Department of Medical & Molecular Genetics, IU School of Medicine
    The statistical identifiability of nonlinear pharmacokinetic (PK) models with the Michaelis-Menten (MM) kinetic equation is considered using a global optimization approach, which is particle swarm optimization (PSO). If a model is statistically non-identifiable, the conventional derivative-based estimation approach is often terminated earlier without converging, due to the singularity. To circumvent this difficulty, we develop a derivative-free global optimization algorithm by combining PSO with a derivative-free local optimization algorithm to improve the rate of convergence of PSO. We further propose an efficient approach to not only checking the convergence of estimation but also detecting the identifiability of nonlinear PK models. PK simulation studies demonstrate that the convergence and identifiability of the PK model can be detected efficiently through the proposed approach. The proposed approach is then applied to clinical PK data along with a two-compartmental model.