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Item Effect of Octreotide on the Colonic Motility in Pediatric Patients with Chronic Recalcitrant Constipation(Lippincott, Williams, and Wilkins, 2015-12) Parashette, Kalyan Ray; Waseem, Shamaila; Horn, Debra; Shah, Aali; Croffie, Joseph; Department of Pediatrics, IU School of MedicineObjective: The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods: This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility. Results: Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03 ± 1.26 (95% confidence interval [CI] 5.35–6.72) and 5.32 ± 1.66 (95% CI 4.42–6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89 ± 1.37 (95% CI 6.14–7.64) and 6.71 ± 1.47 (95% CI 5.91–7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73 ± 1.32 (95% CI 7.01–8.45) and 7.53 ± 1.38 (95% CI 6.78–8.28), respectively, with P value of 0.8. Conclusion: Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.Item Role of Octreotide in Pediatric Gastrointestinal Bleeding Secondary to Angiodysplasia in Children With Right Heart Failure(Wolters Kluwer, 2018-02) Puri, Kanika; Caldwell, Randall L.; Molleston, Jean P.; Pediatrics, School of MedicineObjectives: Angiodysplasia (AD) is a relatively uncommon cause of gastrointestinal bleeding in children and may be seen in right heart failure. Octreotide has been used successfully in adult patients with gastrointestinal bleeding due to ADs. Methods: We describe 2 patients who had congenital heart disease with right heart failure and gastrointestinal bleeding from AD. Results: AD lesions were documented on traditional endoscopy and capsule endoscopy. Bleeding resolved after initiation of IV octreotide and did not recur on subcutaneous octreotide during the 2-year follow-up period. Conclusions: Based on the successful outcomes in the 2 patients, a trial of octreotide may be considered in pediatric patients who present with gastrointestinal bleeding secondary to AD.