Browsing by Subject "metastisis"

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    Early-Stage Metastasis Requires Mdm2 and Not p53 Gain of Function
    (AACR, 2017-11) Hauck, Paula M.; Wolf, Eric R.; Olivos, David J., III; Batuello, Christopher N.; McElyea, Kyle C.; McAtarsney, Ciaran; Cournoyer, R. Michael; Sandusky, George E.; Mayo, Lindsey D.; Pediatrics, School of Medicine
    Metastasis of cancer cells to distant organ systems is a complex process that is initiated with the programming of cells in the primary tumor. The formation of distant metastatic foci is correlated with poor prognosis and limited effective treatment options. We and others have correlated Mouse double minute 2 (Mdm2) with metastasis; however, the mechanisms involved have not been elucidated. Here, it is reported that shRNA-mediated silencing of Mdm2 inhibits epithelial–mesenchymal transition (EMT) and cell migration. In vivo analysis demonstrates that silencing Mdm2 in both post-EMT and basal/triple-negative breast cancers resulted in decreased primary tumor vasculature, circulating tumor cells, and metastatic lung foci. Combined, these results demonstrate the importance of Mdm2 in orchestrating the initial stages of migration and metastasis.
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    Epithelioid Malignant Mesothelioma Metastatic to the Skin: A Case Report and Review of the Literature
    (Wiley, 2017) Ward, Rachel Elizabeth; Ali, Stefanie Ann; Kuhar, Matthew; Department of Dermatology, School of Medicine
    Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to involve the skin and subcutaneous tissue. There is a paucity of reports of cutaneous metastatic mesothelioma, and histologic examination is often challenging because the tumor closely mimics other primary and metastatic neoplasms. We report a case of a 75-year-old man presenting with a firm, hard nodule on his upper back, which on initial histologic evaluation resembled metastatic adenocarcinoma. However, upon review of his medical history and immunohistochemical evaluation of the lesion, the diagnosis of epithelioid MM metastatic to the skin was rendered. The purpose of this case report and review of the literature is to summarize the most effective available immunostains to aid in the diagnosis of this challenging entity, highlight the histologic similarities between metastatic epithelioid MM and other primary and metastatic neoplasms of the skin, and provide prognostic information for these rare tumors.