Browsing by Subject "major depressive disorder"

Now showing 1 - 4 of 4
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    Double Depression is Associated with Greater Risk of Incident Cardiovascular Disease than Major Depression: Data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    (Office of the Vice Chancellor for Research, 2013-04-05) Case, Stephanie M; Sawhney, Manisha; Stewart, Jesse C
    Evidence suggests depressive disorders are risk factors for cardiovascular disease (CVD), however, little attention has been given to double depression (major depressive disorder (MDD) superimposed on dysthymia). The current study sought to determine if double depression is a stronger predictor of incident CVD due to greater duration of exposure and severity of depression in adults initially free of CVD. We analyzed data from 29,581 adults (mean age = 45 years, 58% female, 42% non-white) from Waves 1 (2001-2002) and 2 (2004-2005) of the NESARC study. At Wave 1, the Alcohol Use Disorder and Associated Disabilities Interview Schedule was administered to assess lifetime history of DSM-IV MDD and/or dysthymia. A 4-level variable was created for depression: no depression history (n=24,339), lifetime MDD only (n=4,028), lifetime dysthymia only (n=246), lifetime MDD and dysthymia (double depression; n=968). At Wave 2, participants who reported being diagnosed with myocardial infarction, stroke, angina, or arteriosclerosis in the past year were coded as having incident CVD; those diagnosed with myocardial infarction or stroke were coded as having had a hard CVD event. There were 1,380 CVD events and 365 hard CVD events. Logistic regression models adjusted for demographics (age, sex, race-ethnicity, education) and CVD risk factors (hypertension, hypercholesterolemia, diabetes, smoking, BMI) revealed that lifetime double depression (OR=1.72, 95% CI: 1.31-2.25, p<.001) and MDD only (OR=1.26, 95% CI: 1.06-1.49, p=.01), but not dysthymia only (OR=1.45, 95%, CI: 0.88-2.40, p=.15), predicted incident CVD. Double depression was a stronger predictor than MDD only (p=.04). In models predicting hard CVD events, double depression remained a predictor (OR=1.86, 95% CI: 1.10-3.16, p=.02) but MDD and dysthymia only did not (both ps>.43). Our findings partially support our hypothesis and suggest that persons with double depression may have a stronger connection to an elevated CVD risk in which prevention efforts should be intensified.
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    Is individual cognitive behavioral therapy as effective as antidepressants in patients with major depressive disorder?
    (Wolters Kluwer, 2021-05) Dams, Travis J.; Dhesi, Tajinder S.; Family Medicine, School of Medicine
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    Neurologic Changes and Depression
    (Elsevier, 2018-03) Greene, Ryan D.; Wang, Sophia; Psychiatry, School of Medicine
    This article covers current research on the relationship between depression and cognitive impairment in older adults. First, it approaches the clinical assessment of late-life depression and comorbid cognitive impairment. Cognitive risk factors for suicide are discussed. Research is then provided on neuropsychological changes associated with depression, discussing subjective cognitive impairment, mild cognitive impairment, and dementia profiles. Additionally, literature regarding neuroimaging and biomarker findings in depressed older adults is presented. Finally, therapeutic models for treatment of late-life depression are also discussed, including psychotherapy models, holistic treatments, pharmacologic approaches, and brain-stimulation therapies.
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    Perinatal Psychiatry: Where Psychoanalytic Theory, Neuroscience, and Integrated Clinical Psychiatry Meet
    (UBM Medica, 2017) Chambers, Joanna E.; Psychiatry, School of Medicine