Browsing by Subject "long-term outcomes"

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    Fifteen is just a number
    (Elsevier, 2023-07) Denlinger, Chadrick E.; Surgery, School of Medicine
    Lymph node dissection remains an essential part of any oncologic surgery. At a minimum, sentinel node sampling is required for some cancers. For many solid malignancies, including lung and esophageal cancer, the number of lymph nodes resected correlates with long-term outcomes. The debate remains regarding the relative contributions of the oncologic impact of a thorough lymph node sampling vs stage migration leading to the improved outcomes. An alternative explanation, still, is that a thorough lymph node sampling may just be a surrogate marker of comprehensive quality care, without having any direct impact on cancer-related outcomes.
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    Long Term Consequences of the Fontan Procedure and How to Manage Them
    (Elsevier, 2018) Kay, W. Aaron; Moe, Tabitha; Suter, Blair; Tennancour, Andrea; Chan, Alice; Krasuski, Richard A.; Zaidi, Ali N.; Medicine, School of Medicine
    In 1971, Fontan and Baudet described a surgical technique for successful palliation of patients with tricuspid atresia. Subsequently, this technique has been applied to treat most forms of functional single ventricles and has become the current standard of care for long-term palliation of all patients with single ventricle congenital heart disease. Since 1971, the Fontan procedure has undergone several variations. These patients require lifelong management including a thorough knowledge of their anatomic substrate, hemodynamic status, management of rhythm and ventricular function along with multi organ evaluation. As these patients enter middle age, there is increasing awareness regarding the long-term complications and mortality. This review highlights the long-term outcomes of the Fontan procedure and management of late sequelae.
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    Optimal management of posterior cruciate ligament injuries: current perspectives
    (Dove, 2017-04) Shelbourne, K. Donald; Benner, Rodney W.; Ringenberg, Jonathan D.; Gray, Tinker; Department of Orthopaedic Surgery, IU School of Medicine
    Background: The optimal management of posterior cruciate ligament (PCL) injuries is debated by orthopedic surgeons. A natural history study (NHS) of acute, isolated PCL tears in patients with a mean follow-up of 14.3 years was previously published. The purpose of this study was to compare and contrast the results of the NHS study with those of other studies with similar follow-up time after operative and nonoperative management of isolated PCL tears. Material and methods: With reviewing the literature, six operative management and six nonoperative management studies were found for treating isolated PCL injuries. We analyzed the subjective and objective outcomes of these 12 studies and compared them to the results of the NHS to determine optimal management of PCL injuries. Results: Final follow-up times ranged from a mean of 6.2 to 15 years in the nonoperative studies and 6.3 to 12 years in the operative studies. Side-to-side differences in laxity following surgical management ranged from 1.1 to 7 mm on KT-1000 arthrometer testing and 2.8 to 4.7 mm on Telos stress testing. Tegner scores at final follow-up ranged from 6.6 to 7.7 in nonoperative studies and 5.7 to 7.4 in operative studies. International Knee Documentation Committee scores were 73.4, 82.7, and 84 in nonoperative studies and 65 and 87 in the operative studies. Lysholm scores were 85.2 in the nonoperative study and ranged from 81 to 92.1 in operative studies. Osteoarthritis was reported with ranges from 17% to 88% in nonoperative studies and 13.3% to 63.6% in operative studies. Conclusion: We found that the subjective and objective results in the NHS compare favorably to those of outcomes for PCL reconstruction. Unless a technique is found that can completely restore knee stability, it is unlikely that simply reducing posterior laxity will improve outcomes or prevent the development of osteoarthritis.