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Item An integrative model of the impairments in insight in schizophrenia: emerging research on causal factors and treatments(Taylor & Francis, 2016) Vohs, Jenifer L.; George, Sunita; Leonhardt, Bethany L.; Lysaker, Paul H.; Department of Psychiatry, IU School of MedicineIntroduction: Poor insight, or unawareness of some major aspect of mental illness, is a major barrier to wellness when it interferes with persons seeking out treatment or forming their own understanding of the challenges they face. One barrier to addressing impaired insight is the absence of a comprehensive model of how poor insight develops. Areas covered: To explore this issue we review how poor insight is the result of multiple phenomena which interfere with the construction of narrative accounts of psychiatric challenges, rather than a single social or biological cause. Expert commentary: We propose an integrative model of poor insight in schizophrenia which involves the interaction of symptoms, deficits in neurocognition, social cognition, metacognition, and stigma. Emerging treatments for poor insight including therapies which focus on the development of metacognition are discussed.Item Predicting therapy success from the outset: The moderating effect of insight into the illness on metacognitive psychotherapy outcome among persons with schizophrenia(Wiley, 2019) de Jong, Steven; Hasson-Ohayon, Ilanit; van Donkersgoed, Rozanne J. M.; Timmerman, Marieke E.; van der Gaag, Mark; Aleman, Andre; Pijnenborg, G. H. Marieke; Lysaker, Paul H.; Psychiatry, School of MedicineThe degree to which a person recognizes their mental disorder, attributes symptoms to the disorder, and recognizes that treatment may be necessary is frequently referred to as clinical insight. The current study investigates whether clinical insight at baseline moderates the effects on metacognitive capacity of 40 sessions of metacognitive reflection and insight therapy among 35 participants with psychosis. Findings showed that clinical insight did not predict drop‐out from therapy. Multilevel analyses provided support for our hypotheses that insight at baseline significantly moderates metacognitive gains at both postmeasurement and follow‐up. Our findings demonstrate that lacking clinical insight substantially hampers the effect of this psychosocial intervention. We posit that research efforts should shift from developing interventions, which enhance clinical insight, to interventions, which are effective in absence of clinical insight.