Browsing by Subject "infectious diseases"

Now showing 1 - 3 of 3
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    Cell Signaling Pathways that Regulate Ag Presentation
    (American Association of Immunologists, 2016-10-15) Brutkiewicz, Randy R.; Microbiology and Immunology, School of Medicine
    Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should respond to stress, protecting itself from harm (environmental insults or infections), to ultimately, death by apoptosis. These signaling pathways are important for various aspects of the immune response as well. However, not much is known in terms of the participation of cell signaling pathways in Ag presentation--a necessary first step in the activation of innate and adaptive T cells. In this brief review, I will discuss the known signaling molecules (and pathways) that regulate how Ags are presented to T cells and the mechanism(s) if identified. Studies in this area have important implications in vaccine development and new treatment paradigms against infectious diseases, autoimmunity and cancer.
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    Understanding microbes in sickness and in health
    (2006-01) National Institute of Allergy and Infectious Diseases (U.S.)
    Background information on the causes of infectious diseases. Covers epidemics, pandemics, and avian influenza. The "More Information" section is an annotated bibliography of additional resources.
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    Understanding vaccines: what they are, how they work
    (2003-07) National Institute of Allergy and Infectious Diseases (U.S.)
    Background information on vaccines and vaccination. Includes an extensive glossary.