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Item Isolated Kaposi sarcoma of the upper aerodigestive tract in immunocompetent individuals, an underrecognized entity with favorable prognosis(Sage, 2022-09-15) Shabaan, Abdelrahman; Alkashash, Ahmad; Hou, Tieying; Saeed, Omer; Yesensky, Jessica; Roshal, Anna; Mesa, Hector; Otolaryngology -- Head and Neck Surgery, School of MedicineKaposi sarcoma (KS) is a rare vascular neoplasm that most commonly arises in the setting of immunosuppression, in areas with high prevalence of Human Herpesvirus-8 infection, and when both situations coexist. Most cases affect the skin, isolated involvement of the upper respiratory tract without skin involvement is extremely rare with only a few cases reported in the literature. We present a case of isolated nasopharyngeal KS in an immunocompetent patient who achieved remission after multimodality therapy. Recent advances in KS-therapy are discussed.