Browsing by Subject "imaging methods"

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    IUPUI Imaging Research Initiative: Research Center for Quantitative Renal Imaging
    (Office of the Vice Chancellor for Research, 2014-04-11) Holland, Mark
    Mission: The overall mission of the Research Center for Quantitative Renal Imaging is to provide a focused research environment and resource for the development, implementation, and dissemination of innovative, quantitative imaging methods designed to assess the status of and mechanisms associated with acute and chronic kidney disease and evaluate efficacy of therapeutic interventions. Currently, there is no comprehensive research center within the United States that is solely dedicated to the development of quantitative imaging methods specifically designed to diagnose kidney disease, monitor its progression, and evaluate efficacy of therapeutic interventions. The Research Center for Quantitative Renal Imaging represents a very unique resource within the nephrology and medical imaging communities that is distinctly associated with IUPUI and the IU School of Medicine. Nature of the Center: Our plan is to build upon the individually successful research programs and infrastructure that currently exist within our institution and weave these individual components into a new, unified, and unique Research Center focused on developing novel and innovative methods for quantitative imaging of the kidney. Goals: The Research Center for Quantitative Renal Imaging will achieve its mission by: • Identifying, developing, and implementing innovative imaging methods that provide quantitative imaging biomarkers for assessing and inter-relating renal structure, function, hemodynamics and underlying tissue microenvironmental factors contributing to kidney disease. • Establishing an environment that facilitates and encourages interdisciplinary collaborations among investigators, helps advance the research careers of junior faculty, and offers research support to investigators focused on developing and utilizing innovative quantitative imaging methods in support of kidney disease research. • Providing a resource to inform the greater research and healthcare communities of advances in quantitative renal imaging and its potential for enhanced patient management and care. • Offering an imaging research resource to pharmaceutical companies and medical device manufacturers engaged in product development associated with the diagnosis and treatment of kidney disease.
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    Use of Aperio Whole Slide Imaging System to Capture and Utilize Digital Virtual Slides for Pathology Education
    (Office of the Vice Chancellor for Research, 2014-04-11) Capouch, Samuel; Lipking, Kelsey; Surface, Ronne Leigh; Morgan, Randy; Sandusky, George E.
    Digital whole slide imaging is the technique of digitizing an entire microscope slide at the highest resolution to produce a “digital virtual microscope slide” with high image quality. This digital image can be viewed in three to four fields, from low to high power, a feature commonly used by pathologists. This digital virtual slide can be used in conjunction with image processing software (both windows-based and browser-based) to view, manipulate, position, and specify the magnification of the image on a screen as if using a regular microscope to view the original glass slide. As the slide is captured in a virtual format, it is possible to use the image for archiving, copying, transferring over networks, distant consultation, as well as integration for educational use on the web and/or DVD. In this study, we captured all C603 and C604 sophomore pathology teaching slides in the general and systemic pathology course for viewing and learning through the Aperio ImageScope viewer. The resulting digital images possessed greater ease of use, were quicker to scan and allowed easier location of pathologic lesions in the slides. The ImageScope viewer allowed students to quickly zoom in and out of the slides at multiple fields of magnification. Instructors that have switched to the Aperio system from the old Bliss system found the Aperio system allowed the instructor to open up to 8 slides at one time, allowing side by side comparison to be completed on the same screen. The system also allows one to measure the size of the cells and to capture detailed images of tumor cells, inflammatory cells, and/or necrosis (cell death). This system is available for use on desktop, laptop, and most digital devices (such as smart phones or tablets). Compared to the old Bliss system, which is unable to perform these functions.