Browsing by Subject "humans"

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    The Development of a Wireless Control System for Integration on Drones
    (Office of the Vice Chancellor for Research, 2015-04-17) Allen, Tim; Tovar, Andrés
    The use of remotely controlled drones has proven to assists humans in day to day life. Whether it be by keeping our military personnel safe, defusing bombs, or exploring parts of space humans have not yet reached. The purpose of this project was to develop a control system that can be used on a drone. The control system allows a user to control a radio controlled vehicle up to 300 yards away. It contains a wireless video feedback system so that the user can still control the vehicle even when it is out of the user’s line of sight. The user controls the vehicle with a custom made software package that includes a graphical user interface. The software takes commands from the user and transmits them through the serial port to an xBee module. The xBee module on the vehicle receives the information and transmits it to the microcontroller on the vehicle. The microcontroller then executes necessary commands and sends any feedback required. The software package includes controls for the steering, throttle, and camera control. The outcome of this project is a control system that can be incorporated in to future drone projects. The software is fully documented to make customizing it to individual projects simple. The circuitry on the receiving end of the control system contains serial ports to make it possible to integrate any other peripheral technology in to the existing control system. The end result of this project is a working prototype that will allow future students to build off of. This will expedite further research of drones at IUPUI. Mentor: Andres Tovar, Department of Mechanical Engineering, Purdue School of Engineering and Technology
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    Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers
    (Oxford University Press, 2016-08-01) Singer, Martin; Li, Wei; Morré, Servaas A.; Ouburg, Sander; Spinola, Stanley M.; Microbiology and Immunology, School of Medicine
    Background. In humans inoculated with Haemophilus ducreyi, there are host effects on the possible clinical outcomes—pustule formation versus spontaneous resolution of infection. However, the immunogenetic factors that influence these outcomes are unknown. Here we examined the role of 14 single-nucleotide polymorphisms (SNPs) in 7 selected pathogen-recognition pathways and cytokine genes on the gradated outcomes of experimental infection., Methods. DNAs from 105 volunteers infected with H. ducreyi at 3 sites were genotyped for SNPs, using real-time polymerase chain reaction. The participants were classified into 2 cohorts, by race, and into 4 groups, based on whether they formed 0, 1, 2, or 3 pustules. χ2 tests for trend and logistic regression analyses were performed on the data., Results. In European Americans, the most significant findings were a protective association of the TLR9 +2848 GG genotype and a risk-enhancing association of the TLR9 TA haplotype with pustule formation; logistic regression showed a trend toward protection for the TLR9 +2848 GG genotype. In African Americans, logistic regression showed a protective effect for the IL10 –2849 AA genotype and a risk-enhancing effect for the IL10 AAC haplotype., Conclusions. Variations in TLR9 and IL10 are associated with the outcome of H. ducreyi infection.