- Browse by Subject
Browsing by Subject "gastrointestinal tract"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Colonic Myeloid Sarcoma as a Rare Presentation of Relapsed Acute Myeloid Leukemia(Wolters Kluwer, 2020-06-15) Phatharacharukul, Parkpoom; Fayad, Nabil; Siwiec, Robert; Medicine, School of MedicineMyeloid sarcoma (MS), an extramedullary tumor of immature granulocytic cells, affects the gastrointestinal tract in approximately 10% of cases. MS involvement of the colon and rectum is considered to be extremely rare. We present a 36-year-old woman with acute myeloid leukemia and allogenic hematopoietic stem cell transplant 2 years before who was admitted with abdominal pain and nonmucous, nonbloody diarrhea. Colonoscopy revealed an ulcerated mass in the proximal colon, and biopsies showed MS compatible with acute myeloid leukemia relapse.Item IgA Nephropathy in the Setting of Anti-TNF-α Therapy for Inflammatory Bowel Disease(Wolters Kluwer, 2020-09-01) Strobel, Thomas; Ahmed, Waseem; De la Sancha, Carlo; Bohm, Matthew; Fischer, Monika; Medicine, School of MedicineTumor necrosis factor-α (TNF-α)-inhibiting agents are a standard therapy for moderate-to-severe inflammatory bowel disease (IBD). IgA nephropathy in the setting of prolonged exposure to TNF-α inhibitors is a rare, clinically significant adverse event often overlooked by gastroenterologists but well documented in the rheumatologic literature. We present a case series of 3 patients with IBD on TNF-α inhibitors who developed biopsy-proven IgA nephropathy. Clinicians prescribing TNF-α inhibitors to patients with IBD need to be aware of this potential side effect. Therapies with alternative mechanisms of action should instead be considered.