- Browse by Subject
Browsing by Subject "fertility"
Now showing 1 - 9 of 9
Results Per Page
Sort Options
Item "The Ability Of Women To Conceive Has a Direct Impact On A Woman's Place In Society"(2012-02-09) Rothenberg, JeffItem The Ability of Women to Concieve has a Direct Impact on a Woman's Place in Society(2012-02-09) Rothenberg, JeffItem The Evolution of Modern Sexuality(2011-09-09) Gunderman, Richard B.Item Fertility(2014) Harter, Lynn M.; Bute, Jennifer J.Item Fertility-Related Perceptions and Behaviors among Low-Income Women: Injunctive Norms, Sanctions, and the Assumption of Choice(2010-07) Jensen, Robin E.; Bute, Jennifer J.In this article we explore elements of the theory of normative social behavior (TNSB) through interviews with low-income women (N = 30) in a Midwestern U.S. state about their experiences with and perceptions of fertility-related norms. Using grounded theory and matrix analysis as analytical lenses, we found that individuals sometimes learn of injunctive norms and social sanctions separately, might be more likely to comply with a norm if they learn about norms and sanctions in concert, and might be more likely to engage in norm compliance if they learn about two different types of sanctions, short- and long-term, along with the injunctive norm. We also found that a number of important barriers can limit one’s ability to choose to comply with a norm. In conclusion, we discuss implications for continued theorizing of the TNSB in light of the experiences of traditionally marginalized populations.Item "Fitter Families, Better Babies, and Reproductive Control"(2005-10-10) Stern, AlexandraItem Intrauterine device use, sexually transmitted infections, and fertility: a prospective cohort study(Elsevier, 2021-08) Peipert, Jeffrey F.; Zhao, Qiuhong; Schreiber, Courtney; Teal, Stephanie; Turok, David K.; Natavio, Melissa; Cordon, Sabrina; Daggy, Joanne; Obstetrics and Gynecology, School of MedicineBackground In the 1970s, numerous medical reports, media coverage, and litigation around the Dalkon Shield intrauterine device led to a perception that all intrauterine devices cause upper genital tract infection and infertility. Objective This study aimed to assess the association between intrauterine device use and time to conception. Study Design The Fertility After Contraceptive Termination Study is a multicenter, prospective cohort study of women stopping their contraceptive method to attempt conception. We recruited participants between 2011 and 2017. Participants were a convenience sample of women recruited from academic centers in Philadelphia, PA; Los Angeles, CA; St. Louis, MO; Indianapolis, IN; Aurora, CO; and Salt Lake City, UT. Women were eligible if they stopped their contraceptive method within the past 120 days before enrollment, were between 18 and 35 years of age, had no history of infertility or sterilization, and had at least 6 months of follow-up. Baseline data included demographic and reproductive characteristics, past contraceptive use, nucleic acid amplification testing for sexually transmitted infections, and serology for past infection with Chlamydia trachomatis, Trichomonas vaginalis, and Mycoplasma genitalium. The primary exposure was intrauterine device use (ever); the primary outcome was time to conception. All participants were observed longitudinally for up to 24 months. We used piecewise exponential proportional hazards models with multiple imputation to provide hazard ratios and their respective 95% confidence intervals. Results Of the 461 participants, mean age was 28.2 years, 178 (38.7%) were Black, 157 (34.1%) were considered as low socioeconomic status, and 275 (59.7%) had a history of intrauterine device use. Without adjusting for any covariates, the median time to conception was shorter for participants who had a history of intrauterine device use (5.1 months) than participants who never used an intrauterine device (7.5 months). After controlling for potential confounders, the association of past intrauterine device use with time to conception was not statistically significant (adjusted hazard ratio, 1.25; 95% confidence interval, 0.99–1.58). In our multivariable model, age, nulligravidity, Black race, low socioeconomic status, and past Mycoplasma genitalium infection were associated with longer times to conception (hazard ratio, 0.76; 95% confidence interval, 0.58–0.99). Conception by 12 months was lower in participants with past Mycoplasma genitalium infection (68% vs 80% without past infection; P=.019). Conclusion We found no impairment of fertility with ever use of an intrauterine device. Serologic evidence of past Mycoplasma genitalium infection was associated with longer times to conception and higher rates of infertility. Mycoplasma genitalium infection is a potential modifiable cause of infertility.Item Obesity and Fertility: A Prospective Cohort Study(2020-07-31) Burger, Taylor; Li, Joanna; Zhao, Qiuhong; Peipert, Jeffrey F.Background and Hypothesis: Previous studies have linked body mass index (BMI) with time to pregnancy. The objective of this analysis was to determine if obesity (BMI > 30 kg/m2) is associated with reduced fertility in a cohort of women who discontinued contraceptive method to attempt conception. We hypothesized that BMI is associated with time to conception after controlling for potential confounding variables. Methods: We performed a secondary analysis of the FACT (Fertility After Contraceptive Termination) study. We included 432 women, aged 18-35 years old, who discontinued contraception in an effort to conceive, were sexually active with a male partner, had the ability to consent, and had a minimum of 12 months of follow-up data. Participants were excluded who were already pregnant, had a history of infertility or medically induced sterility or, used depot medroxyprogesterone acetate (DMPA) in the past 5 months. We collected participant data on demographic, reproductive, medical characteristics, and sexual history, as well as date of contraceptive termination. We used Cox proportional hazard models to assess associations between BMI and time to conception while controlling for race, socioeconomic status, and prior contraceptive method. Results: A BMI of 30 or greater was associated with reduced fertility compared to participants with a BMI of less than 25 after controlling for race, low SES, and prior contraceptive method (HRadj=0.72; 95% CI 0.53, 0.97; p=0.03). We also noted that obese women with regular menses had reduced fertility compared to normal weight participants with regular cycles (HRadj 0.58; 95% CI 0.39, 0.86, p=0.007). For participants with irregular menstrual cycles, BMI was not associated with time to conception. Conclusion & Potential Impact: Our study supports the association of obesity with reduced fertility and increased time to conception. Future studies of weight loss should be considered as a method to improve conception rates.Item Recurrent Metastatic High‑Grade Osteosarcoma: Disease Stabilization and Successful Pregnancy Outcome following Aggressive Multimodality Treatment(Wolters Kluwer, 2018) Khurana, Monica; Gruner, Barbara; Sathi, Bindu Kanathezhath; Medicine, School of MedicinePrognosis for refractory/recurrent metastatic osteosarcoma (OS) remains dismal with 3-year survival rates <20%. Achievement of more than 5 years of stable, refractory/recurrent metastatic OS disease in our patient is itself unique and attributable to multimodality therapy. Her high-dose chemotherapy regimen with alkylating agents did not lead to infertility, making her case even more unique. Successful disease stabilization and pregnancy outcome in our patient with metastatic multiple relapsed OS is one of the first cases published. We need further understanding and exploration of pathogenesis, chemoresistant mechanisms, and multimodality therapies including immunotherapy for OS.