Browsing by Subject "desensitization"

Now showing 1 - 3 of 3
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    Enhancing Hand Sensation and Health Literacy in Hand Therapy
    (2025) Mukhtar, Anam; Albright , Megan; Department of Occupational Therapy, School of Health and Human Sciences; Edsell, Amanda
    Hand and upper extremity injuries, especially those that result in nerve damage, can lead to sensory loss, pain, and functional impairments. Despite the frequency of these diagnoses seen in outpatient hand therapy, many patients lack the health literacy necessary to fully comprehend and actively participate in desensitization and sensory re-education interventions. Research suggests that implementing a sensory-based approach as part of treatment sessions can play a vital role in addressing hypersensitivity and sensory loss. The purpose of this doctoral capstone experience is to bridge that gap by implementing a program that includes providing take-home sensory kits and educational handouts focused on improving sensation, managing pain, and promoting increased functional use of the upper extremity. By promoting health literacy and providing accessible tools, the project’s goal is to increase client engagement in both therapy and functional daily tasks. The capstone student prepared for this by gaining clinical practice skills in an outpatient hand setting and conducting literature reviews. With the skills gained through preparation, the capstone student developed take-home sensory kits and educational handouts to address patients’ concerns with sensitivity in their upper extremities. To assess the effectiveness of the tools, a pre- and post-interview was performed with the site’s content expert. The results suggested that the interventions helped reduce pain, improve sensation, and foster a deeper understanding of the benefits of evidence-based interventions to promote client participation.
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    PAP Desensitization Handout for Patients
    (2021-04-04) Stahl, Stephanie M.
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    PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity
    (MDPI, 2014-04-04) Chen, Xingjuan; Egly, Christian; Riley, Ashley M.; Li, Wennan; Tewson, Paul; Hughes, Thomas E.; Quinn, Anne Marie; Obukhov, Alexander G.; Cellular and Integrative Physiology, School of Medicine
    Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulosclerosis. When stimulated by agonists of the histamine H1 receptor (H1R), TRPC6 activity decays to the baseline despite the continuous presence of the agonist. In this study, we examined whether H1R desensitization contributes to regulating the decay rate of TRPC6 activity upon receptor stimulation. We employed the HEK expression system and a biosensor allowing us to simultaneously detect the changes in intracellular diacylglycerol (DAG) and Ca2+ concentrations. We found that the histamine-induced DAG response was biphasic, in which a transient peak was followed by maintained elevated plateau, suggesting that desensitization of H1R takes place in the presence of histamine. The application of PKC inhibitor Gö6983 slowed the decay rate of intracellular DAG concentration. Activation of the mouse H1R mutant lacking a putative PKC phosphorylation site, Ser399, responsible for the receptor desensitization, resulted in a prolonged intracellular DAG increase and greater Mn2+ influx through the TRPC6 channel. Thus, our data support the hypothesis that PKC-dependent H1R phosphorylation leads to a reduced production of intracellular DAG that contributes to TRPC6 activity regulation.