Browsing by Subject "dermatology"

Now showing 1 - 6 of 6
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    Analysis of conflicts of interest in pharmaceutical payments made to Food and Drug Administration physician advisers after dermatologic drug approval
    (Elsevier, 2019) Kuschel, Stephanie L.; Ricotti, Claudia M.; Dunnick, Cory A.; Hugh, Jeremy; Dellavalle, Robert P.; Medicine, School of Medicine
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    Central neural activation following contact sensitivity peripheral immune challenge: evidence of brain–immune regulation through C fibres.
    (Wiley, 2015-10) Thinschmidt, Jeffrey S.; King, Michael A.; Korah, Maria; Perez, Pablo D.; Febo, Marcelo; Miyan, Jaleel; Grant, Maria B.; Department of Ophthalmology, IU School of Medicine
    This study tested the hypothesis that peripheral immune challenges will produce predictable activation patterns in the rat brain consistent with sympathetic excitation. As part of examining this hypothesis, this study asked whether central activation is dependent on capsaicin-sensitive C-fibres. We induced skin contact sensitivity immune responses with 2,4-dinitrochlorobenzene (DNCB), in the presence or absence of the acute C-fibre toxin capsaicin (8-methyl-N-vanillyl-6-nonenamide) to trigger immune responses with and without diminished activity of C-fibres. Innovative blood-oxygen-level-dependent functional magnetic resonance imaging data revealed that the skin contact sensitivity immune responses induced with DNCB were associated with localized increases in brain neuronal activity in treated rats. This response was diminished by pre-treatment with capsaicin 1 week before scans. In the same animals, we found expression of the immediate early gene c-Fos in sub-regions of the amygdala and hypothalamic sympathetic brain nuclei. Significant increases in c-Fos expression were found in the supraoptic nucleus, central amygdala and medial habenula following immune challenges. Our results support the idea that selective brain regions, some of which are associated with sympathetic function, process or modulate immune function through pathways that are partially dependent on C-fibres. Together with previous studies demonstrating the motor control pathways from brain to immune targets, these findings indicate a central neuroimmune system to monitor host status and coordinate appropriate host responses.
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    Characterization of medical malpractice lawsuits relating to dermatologic emergencies in the inpatient and emergency setting
    (Elsevier, 2020) Rumancik, Brad; Keele, Benjamin J.; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
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    The current state of lesbian, gay, bisexual and transgender (LGBT) cultural competency among U.S. dermatology residents
    (Wolters Kluwer, 2022-10) Nowaskie, Dustin Z.; Garcia-Dehbozorgi, Sara; Cortez, Jose L.; Medicine, School of Medicine
    Background: Lesbian, gay, bisexual, and transgender (LGBT) people interface with dermatology providers for many reasons. Implementing culturally competent LGBT dermatologic care necessitates evaluating provider competency to identify where gaps remain. Objectives: To assess the LGBT cultural competency among U.S. dermatology residents. Methods: A self-reporting, cross-sectional survey was emailed to U.S. dermatology program coordinators (N = 143). LGBT patient exposure, LGBT educational hours, and LGBT cultural competency via the LGBT-Development of Clinical Skills Scale (with the subscales Clinical Preparedness, Attitudinal Awareness, and Basic Knowledge) were measured. Results: Dermatology residents (N = 119) across the United States completed the survey. They reported caring for less than 20 LGBT patients per year and receiving less than 75 minutes of LGBT education per year. They reported significantly higher Attitudinal Awareness than both Clinical Preparedness and Basic Knowledge; they reported significantly higher Basic Knowledge than Clinical Preparedness. They reported significantly less adequate clinical training and supervision, experience, and competence to assess transgender patients compared to lesbian, gay, and bisexual patients. In general, dermatology residents who reported more LGBT patients and LGBT education also reported higher LGBT cultural competency. Limitations: A larger national sample of U.S. dermatology residents is necessary for generalizability. Conclusions: Currently, there is a lack of LGBT education in U.S. dermatology residency curricula, which may delay addressing the health disparities that exist in this patient population. Due to such dearth of standardized LGBT education, dermatology residents likely do not feel adequately knowledgeable or prepared to address LGBT needs. Both LGBT education and LGBT patient experiences may help alleviate these shortcomings and help LGBT patients feel affirmed in their dermatologic care.
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    Dermatologic manifestations of vascular access steal syndrome
    (Our Dermatology Online, 2020) Hekman, Daniel; Burton, Kyle; Rahnama-Moghadam, Sahand; Dermatology, School of Medicine
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    Litigation arising from the use of soft-tissue fillers in the United States
    (2015-09-14) Ezra, Navid; Peacock, Elizabeth Anne; Keele, Benjamin J.; Kingsley, Melanie