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Item Alveolar Ridge Augmentation Around Exposed Mandibular Dental Implant With Histomorphometric Analysis(Wiley, 2021-03) Ibraheem, Ahmed Gamil; Blanchard, Steven B.; Periodontology, School of DentistryIntroduction Alveolar ridge augmentation either before or during implant placement is a predictable procedure under certain conditions. A major complication during the healing phase is incision line opening and membrane exposure, which may result in reduced bone gain and reduced implant survival. This case report describes alveolar bone regeneration around three dental implants despite membrane exposure that developed during healing post-surgically. Case Presentation A 72-year-old female presented requesting dental implants to replace tooth numbers 18, 19, and 20. A cone-beam computed tomography (CBCT) scan showed loss of horizontal and vertical ridge dimensions. All implants were placed with a variable degree of implant thread exposure on their buccal surfaces, ranging from 3 to 4.5 mm. Simultaneous bone grafting was performed using freeze dried bone allograft and deproteinized bovine bone mineral that was covered by a d-PTFE membrane that was secured with tacking screws. Primary closure was obtained, and flaps were sutured. Three weeks post-surgically, membrane exposure occurred. Exposure was monitored and patient was instructed to follow strict oral hygiene instructions around the exposed membrane. Membrane exposure gradually increased without infection and was removed at 16 weeks. Membrane removal revealed dense fibrous tissues covering all implant surfaces. At the second stage surgery, new bone was seen covering all the implants coronal to the cover screws. A trephine core biopsy specimen revealed significant new bone formation and connective tissue around any residual grafted bone. Conclusion d-PTFE membrane exposure does not necessarily lead to adverse healing outcomes for alveolar ridge augmentation if handled properly with close patient follow-up.Item Comparative evaluation of mandibular canal visibility on crosssectional cone-beam CT images: a retrospective study(British Institute of Radiology, 2015) Miles, Mahogany S.; Parks, Edwin T.; Eckert, George J.; Blanchard, Steven B.; Department of Periodontics and Allied Dental Programs, IU School of DentistryOBJECTIVES: The purpose of this study was to determine the visibility of the mandibular canal (MC) in CBCT images and if the visibility of the MC is affected by gender, location and/or age. METHODS: CBCT images were evaluated for the visibility of the MC by a board-certified oral and maxillofacial radiologist, a board-certified periodontist and a periodontics resident. Representative slices were examined for the first premolar (PM1), second premolar (PM2), first molar (M1) and second molar (M2) sites by all examiners. The visibility of the MC was registered as either present or absent. RESULTS: 360 total CBCT cross-sectional images were examined, with the MC identified in 204 sites (56%). Age had a significant effect on MC visibility, but it differed by location: for PM1, age 47–56 had lower visibility than age 65+ (p = 0.0377). Gender also had a significant effect on canal visibility, where females had lower visibility than males overall (p = 0.0178) and had the most pronounced difference for PM1 (p = 0.0054). Location had a significant effect on visibility, but it differed by age and by gender: for age 65+, M2 had lower visibility than PM1 (p = 0.0411) and PM2 (p = 0.0180), while for females, PM1 had lower visibility than M1 (p = 0.0123) and M2 (p = 0.0419). CONCLUSIONS: The MC was visualized only in just over half of the CBCT images. Age, gender and location had significant effects on the visibility.Item Digital planning and guided surgery in dental implants: a case report(Elsevier, 2019-05) Zanettini, L.; Zanettini, P.; Polido, W.; Pagnoncelli, R.; Oral and Maxillofacial Surgery and Hospital Dentistry, School of DentistryBackground: Dental implants are constantly evolving, with several new technologies. Nowadays, it is the most sought after treatment option for individuals who are candidates for oral rehabilitation, improving esthetics and recovering masticatory capacity. Always in search of minimally invasive procedures, dentistry has sought ways to decrease surgical time, decrease morbidity and greater safety of the surgical procedure. Based on these searches digital planning and guided surgery are being widely used, with the possibility of greater predictability and precision in the planning of dental implants, giving greater chances of successful surgery along with the technique performed correctly.Item Number of implants placed for complete‐arch fixed prostheses: A systematic review and meta‐analysis(Wiley, 2018-10) Polido, Waldemar Daudt; Aghaloo, Tara; Emmett, Thomas W.; Taylor, Thomas D.; Morton, Dean; Oral and Maxillofacial Surgery and Hospital Dentistry, School of DentistryObjectives The main purpose of this systematic review was to evaluate outcomes related to the number of implants utilized to support complete‐arch fixed prostheses, both for the maxilla and the mandible. Materials and methods This review followed the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA). A focused question using the PICO format was developed, questioning whether “In patients with an implant supported fixed complete dental prosthesis, do implant and prosthetic survival outcomes differ between five or more compared to fewer than five supporting implants?”. A comprehensive search of the literature was formulated and performed electronically and by hand search. Two independent reviewers selected the papers and tabulated results. Primary outcomes analyzed were implant and prosthesis survival. Implant distribution, loading, and type of retention were observed as secondary outcomes, as they relate to the number of implants. A meta‐analysis was performed to compare results for studies by number of implants. Results The search strategy identified 1,579 abstracts for initial review. Based on evaluation of the abstracts, 359 articles were identified for full‐text evaluation. From these, 93 were selected and included in this review, being nine RCTs, 42 prospective and 42 retrospective. Of the 93 selected studies, 28 reported number of implants for the maxilla, 46 for the mandible, and 19 for both maxilla and mandible. The most reported number of implants for the “fewer than five” group is 4 for the maxilla, and 3 and 4 for the mandible, whereas for the “five or more” implants group, the most reported number of implants was 6 for the maxilla and 5 for the mandible. No significant differences in the primary outcomes analyzed were identified when fewer than five implants per arch were compared with five or more implants per arch (p > 0.05), in a follow‐up time ranging from 1 to 15 years (median of 8 years). Conclusions Evidence from this systematic review and meta‐analysis suggests that the use of fewer than five implants per arch, when compared to five or more implants per arch, to support a fixed prosthesis of the completely edentulous maxilla or mandible, present similar survival rates, with no statistical significant difference at a p < 0.05 and a confidence interval of 95%.Item Role of Medication in Osseointegration of Dental Implants(2019-05) Ibraheem, Ahmed; Batra, Chandni; John, Vanchit; Shin, Daniel; Periodontology, School of DentistryItem ROLE OF OSTEOCLASTS IN THE BIOCORROSION OF METAL IMPLANTS(Office of the Vice Chancellor for Research, 2011-04-08) Theriac, Haili; Dodge, Todd; Largura, Heather; Hara, A.; Liu, S.; Bruzzaniti, AngelaMini implants (MIs), typically composed of stainless steel (SS) or titanium alloy (Ti), have recently emerged as superior alternatives to traditional dental and orthopedic implants. When a metal implant is inserted into bone, a process called bone remodeling is triggered near the implant. Bone remodeling involves the activity of osteoblasts (OBs), which produce new bone tissue, and osteoclasts (OCs), which degrade and digest bone. OCs degrade bone by acidifying the extracellular environment and secreting hydrolytic enzymes that degrade the extracellular matrix. However, the acidification of the extracellular environment can potentially lead to the biological corrosion of metal implants after implantation. This may have important consequences such as cell toxicity, decreased osseointegration of the implant, and implant loosening. The objective of this study is to determine if implants made from Ti are more resistant to OC-mediated biocorrosion than stainless steel (SS) implants. We hypothesize that biocorrosive activity by OCs will be greater on SS than titanium. To assess the biocorrosive effects of OCs on SS and Ti, the top face of 150 µm thick sections of each metal were scanned using a Proscan 2000 Scantron to provide accurate three dimensional surface measurements of the metals before introduction of OCs. OC precursors were isolated from the bone marrow of C57/bl6 mice and differentiated with macrophage colony stimulating factor and receptor activator of NF-kappaB ligand for 7 days in the presence of either SS or Ti metals. The metals discs were then removed and rescanned with the Proscan Scantron and changes in the surface measurements before and after OC growth was calculated. OCs were fixed and stained for tartrate-resistant acid phosphatase, a marker of mature OCs, and counted. Our preliminary findings revealed that the surface roughness of SS was reduced to a greater extent than Ti metals. OC number was also reduced in cultures containing SS compared with Ti. These findings suggest SS may be more susceptible to OC-mediated biocorrosion than Ti-based metal implants. Although the physiological implications are unclear, we speculate that sustained corrosion of SS can negatively affect the long-term stability of implants in vivo.Item Using an existing surgical template as an aid for a virtual interocclusal record(Elsevier, 2020-09) Lin, Wei-Shao; AlQallaf, Hawra; Morton, Dean; Prosthodontics, School of DentistryA satisfactory complete denture can be duplicated with acrylic resin to preserve the information on the patient’s occlusal vertical dimension, occlusal relationship, and tooth arrangement during preoperative planning for dental implant treatment.1 The duplicated denture can be used as a radiographic template, surgical template, and occlusally adapted custom tray.2 A dual scan protocol with the existing complete denture and additively manufactured surgical template (in the shape of a duplicated denture) is commonly used in contemporary static computer-aided implant surgery (s-CAIS). Occlusion with the opposing arch is often needed to properly position these surgical templates before the s-CAIS.3 As these surgical templates are designed and manufactured from the 3D volumetric data of the existing denture, preserving the interocclusal relationship, this technique allows the clinicians to use the surgical template as an aid to obtain a virtual interocclusal record during intraoral scanning. The acquired intraoral scan and virtual interocclusal record can be used for fabricating a computer-aided design and computer-aided manufacturing (CAD-CAM) implant prosthesis.