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Item Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis(Elsevier, 2018) Wu, Yan; Yuan, Xue; Perez, Kristy C.; Hyman, Sydnee; Wang, Liao; Pellegrini, Gretel; Salmon, Benjamin; Bellido, Teresita; Helms, Jill A.; Anatomy and Cell Biology, School of MedicineVertebrate teeth are attached to the jawbones using a variety of methods but in mammals, a fibrous connection is the norm. This fibrous periodontal ligament (PDL) allows teeth to move in the jawbones in response to natural eruptive forces, mastication, and orthodontic tooth movement. In some disease states the PDL either calcifies or is replaced by a mineralized tissue and the result is ankylosis, where the tooth is fused to the alveolar bone. To understand how the PDL maintains this fibrous state we examined a strain of mice in which tooth movement is arrested. DaβcatOt mice express a stabilized form of β-catenin in DMP1-positive alveolar bone osteocytes and cementocytes, which results in elevated Wnt signaling throughout the periodontium. As a consequence, there is an accrual of massive amounts of cellular cementum and alveolar bone, the PDL itself calcifies and teeth become ankylosed. These data suggest that to maintain its fibrous nature, Wnt signaling must normally be repressed in the PDL space.Item The future of faculty recruitment: Inspiring students into an academic career(Wiley, 2024-03-27) Wong, Cynthia L.; Melo, Mary Anne S.; Scarpa-Lota, Nathalie; Moazzez, Rebecca; Furness, Alan; Stewart, Kelton T.; Orthodontics and Oral Facial Genetics, School of DentistryThe dilemma surrounding faculty shortages within dental education continues to present significant challenges for the dental profession. There remains a tremendous need to create an effective and sustainable pathway for the recruitment of faculty into dental academia, with an emphasis on the establishment of a more diverse and representative faculty composition. This perspective paper proposes a blueprint to nurture and inspire dental students into academia.