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Item Age Differences in the Association of Obstructive Sleep Apnea Risk with Cognition and Quality of Life(Wiley, 2014-02) Addison-Brown, Kristin J.; Letter, Abraham J.; Yaggi, Klar; McClure, Leslie A.; Unverzagt, Frederick W.; Howard, Virginia J.; Lichtman, Judith H.; Wadley, Virginia G.; Department of Psychiatry, IU School of MedicineUsing a sample of 2925 stroke-free participants drawn from a national population-based study, we examined cross-sectional associations of obstructive sleep apnea risk (OSA) with cognition and quality of life and whether these vary with age, while controlling for demographics and co-morbidities. Included participants from the REasons for Geographic And Racial Differences in Stroke Study were aged 47-93. OSA risk was categorized as high or low based on responses to the Berlin Sleep Questionnaire. Cognitive function was assessed with standardized fluency and recall measures. Depressive symptoms were assessed with the four-item Center for Epidemiologic Studies Depression Scale. Health-related Quality of Life (HRQoL) was assessed with the Medical Outcomes Study Short Form-12 (SF-12). MANCOVA statistics were applied separately to the cognitive and quality of life dependent variables while accounting for potential confounders (demographics, co-morbidities). In fully adjusted models, those at high risk for OSA had significantly lower cognitive scores (Wilks’ Lambda = 0.996, F(3, 2786) = 3.31, p < .05) and lower quality of life (depressive symptoms and HRQoL) (Wilks’ Lambda = 0.989, F(3, 2786) = 10.02, p < .0001). However, some of the associations were age-dependent. Differences in cognition and quality of life between those at high and low obstructive sleep apnea risk were most pronounced during middle age, with attenuated effects after age 70.Item Evaluating Differences in Cognitive Function after N-Acetyl-Cysteine Treatment in a Two-Hit Rat Model of Schizophrenia(Office of the Vice Chancellor for Research, 2014-04-11) Cayetano, Nadalie K. J.; Janetsian, Sarine S.; Lapish, Christopher C.Schizophrenia (SZ) is a chronic mental disorder characterized by positive and negative symptoms both of which impair normal functioning. Effective treatment options for negative and cognitive symptoms are non-existent. Identifying translational biomarkers that can be applied across species could aid drug development. Remediation of cognitive impairments will be assessed after administering N-Acetyl-Cysteine (NAC) by the use of validated measures of cognitive performance in a “two-hit” model of SZ. Pups of Sprague Dawley dams were used. Each litter was split into two groups: maternally deprived (MD) or sham. The MD group (n= 9) were weighed and removed from their mothers for 24 hours on post-natal day 9. MD acts as an early-life stressor and may be linked with the development of SZ. The sham group (n= 9) served as controls. On post-natal day 75-88, MD rats (n= 9) received an injection of NAC (90.0 mg/kg; n= 5) or saline (n= 4). All sham rats received saline. Two days after NAC treatment, all rats received an acute injection of Phencyclidine (PCP) at 2.0 mg/kg, an N-Methyl-D-Aspartate antagonist. PCP alters glutamatergic signaling and is the second model used to induce SZ. The day after injection, short-term memory was assessed using temporal order and novel object recognition tasks. The same tasks were given to assess alterations of glutamatergic signaling after receiving chronic 2.0 mg/kg of PCP injections for six days. Preliminary results indicate no detectable differences in temporal order and novel object recognition tasks between the MD groups who received NAC from those who received saline. No significant differences were found between the MD and sham groups that received saline. Furthermore, there were no differences between any of the groups after chronic PCP administration. Additional animals are being tested to increase group sizes and to have larger power when running the analyses.Item Higher blood cadmium level is associated with greater cognitive decline in rural Chinese adults aged 65 or older(Elsevier, 2021-02) Liu, Hang; Su, Liqin; Chen, Xi; Wang, Sisi; Cheng, Yibin; Lin, Shaobin; Ding, Liang; Liu, Jingyi; Chen, Chen; Unverzagt, Frederick W.; Hake, Ann M.; Jin, Yinlong; Gao, Sujuan; Psychiatry, School of MedicineCadmium (Cd) exposure has been reported to have neurotoxic effects in animal studies and associated with increased Alzheimer's Disease mortality and lower cognitive function in cross-sectional and case-control studies. However, no results from longitudinal studies on Cd and cognitive decline are available. In this prospective cohort study, we recruited 1867 participants aged 65 years or older from rural areas in China, blood Cd and cognitive function were measured at baseline (2010−2012), and 1554 participants completed cognitive function tests during a 3-year follow-up (2013–2015). Cognitive function was evaluated using nine standardized cognitive tests: The Community Screening Instrument for Dementia, the CERAD Word List Learning, Word list recall, IU Story Recall, Animal Fluency Test, Boston Naming Test, Stick Design, Delayed Stick Design and the IU Token Test. Analysis of covariance models and logistic regression models were used to determine the association between Cd and standardized cognitive decline adjusting for covariates. The median blood Cd concentration of this study population was 2.12 μg/L, and the interquartile range was 1.42–4.64 μg/L. Significant association of higher Cd levels with lower cognitive scores were observed in five individual cognitive tests (Delayed Stick Design Test, Boston Naming Test, CERAD Word List Learning Test, Word List Recall Test and IU Story Recall Test) and the composite cognitive score adjusting for multi-covariates at baseline. Higher Cd levels were significantly associated with greater 3-year cognitive decline in Delayed Stick Design Test, Boston Naming Test, IU Token Test, Word List Recall Test and Composite cognitive score. For these cognitive tests, participants in the top two Cd quartile groups had significantly greater decline than those in the lowest Cd quartile group, while the two lowest Cd quartile groups were not significantly different. Our findings suggest that higher Cd exposure is associated with greater cognitive decline in older Chinese adults.Item The relationship between cholesterol and cognitive function is homocysteine-dependent(Dove Press Ltd, 2014-10-23) Cheng, Yibin; Jin, Yinlong; Unverzagt, Frederick W.; Su, Liqin; Yang, Lili; Ma, Feng; Hake, Ann M.; Kettler, Carla; Chen, Chen; Liu, Jingyi; Bian, Jianchao; Li, Ping; Murrell, Jill R.; Hendrie, Hugh C.; Gao, Sujuan; Department of Biostatistics, School of MedicineIntroduction Previous studies have identified hyperlipidemia as a potential risk factor for dementia and Alzheimer’s disease. However, studies on cholesterol measured in late-life and cognitive function have been inconsistent. Few studies have explored nonlinear relationships or considered interactions with other biomarker measures. Methods A cross-sectional sample of 1,889 participants from four rural counties in the People’s Republic of China was included in this analysis. Serum total cholesterol, high-density lipoprotein, triglycerides, and homocysteine levels were measured in fasting blood samples. A composite cognitive score was derived based on nine standardized cognitive test scores. Analysis of covariance models were used to investigate the association between biomarker measures and the composite cognitive scores. Results There was a significant interaction between the homocysteine quartile group and the cholesterol quartile group on cognitive scores (P=0.0478). In participants with normal homocysteine levels, an inverse U-shaped relationship between total cholesterol level and cognitive score was found, indicating that both low and high cholesterol levels were associated with lower cognitive scores. In participants with high homocysteine levels, no significant association between cholesterol and cognition was found. Conclusion The relationship between cholesterol levels and cognitive function depends upon homocysteine levels, suggesting an interactive role between cholesterol and homocysteine on cognitive function in the elderly population. Additional research is required to confirm our findings in other populations, and to explore potential mechanisms underlying the lipid–homocysteine interaction.