Browsing by Subject "clinicopathologic risk factors"

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    Enhanced metastatic risk assessment in cutaneous squamous cell carcinoma with the 40-gene expression profile test
    (Future Medicine, 2022-03) Ibrahim, Sherrif F.; Kasprzak, Julia M.; Hall, Mary A.; Fitzgerald, Alison L.; Siegel, Jennifer J.; Kurley, Sarah J.; Covington, Kyle R.; Goldberg, Matthew S.; Farberg, Aaron S.; Trotter, Shannon C.; Reed, Kenneth; Brodland, David G.; Koyfman, Shlomo A.; Somani, Ally-Khan; Arron, Sarah T.; Wysong, Ashley; Dermatology, School of Medicine
    Aim: To clinically validate the 40-gene expression profile (40-GEP) test for cutaneous squamous cell carcinoma patients and evaluate coupling the test with individual clinicopathologic risk factor-based assessment methods. Patients & methods: In a 33-site study, primary tumors with known patient outcomes were assessed under clinical testing conditions (n = 420). The 40-GEP results were integrated with clinicopathologic risk factors. Kaplan–Meier and Cox regression analyses were performed for metastasis. Results: The 40-GEP test demonstrated significant prognostic value. Risk classification was improved via integration of 40-GEP results with clinicopathologic risk factor-based assessment, with metastasis rates near the general cutaneous squamous cell carcinoma population for Class 1 and ≥50% for Class 2B. Conclusion: Combining molecular profiling with clinicopathologic risk factor assessment enhances stratification of cutaneous squamous cell carcinoma patients and may inform decision-making for risk-appropriate management strategies.