Browsing by Subject "benzothiazionones"

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    Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety
    (Elsevier, 2018-05) Lv, Kai; Tao, Zeyu; Liu, Qian; Yang, Lu; Wang, Bin; Wu, Shuo; Wang, Apeng; Huang, Menghao; Liu, Mingliang; Lu, Yu; Medicine, School of Medicine
    We herein report the design and synthesis of benzothiazinones containing a piperidine moiety as new antitubercular agents based on the structure feature of IMB-ZR-1 discovered in our lab. Some of them were found to have good in vitro activity (MIC < 1 μg/mL) against drug-susceptible Mycobacterium tuberculosis H37RV strain. After two set of modifications, compound 2i were found to display comparable in vitro anti-TB activity (MIC < 0.016 μg/mL) to PBTZ169 against drug-sensitive and resistant mycobacterium tuberculosis strains. Compound 2i also showed acceptable PK profiles. Studies to determine PK profiles in lung and in vivo efficacy of 2i are currently under way.