Browsing by Subject "amputation"

Now showing 1 - 3 of 3
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    The Connection Between Regenerative Features of Salamander Limbs and Mammalian Somatic Cells
    (Office of the Vice Chancellor for Research, 2010-04-09) Rao, Nandini; Jhamb, Deepali
    The unique regenerative feature of urodele salamander limbs is their natural ability to dissolve tissue organization and re-program somatic cells to adult stem-like cells at the site of an amputation to create a blastema that self-organizes the missing limb parts. To understand this information, we used quantitative LC/MS/MS peptide separation to analyze temporal changes in proteins after amputation of axolotl hind limbs. The information from this study will be useful in devising chemical induction strategies to reprogram mammalian somatic cells or activate resident stem cells directly at the site of injury to regenerate damaged tissues and appendages.
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    Exploring How Expressive Art Interventions Impact Adults with Amputations
    (2022) Murphy, Baley; Misluk, Eileen; Alpers, Joan
    This study aims to understand how expressive art therapy interventions can impact adults with amputations. The 44 resources implemented in this thesis helped build a literary foundation and formulated themes seen within the literature. These themes included distorted self-image, feelings of loss and grief, complications with adjustment in daily life and with a prosthesis, phantom limb pain, changes to independent living and autonomy, and inadequate education pre- and-post-amputation. Four groups were proposed to inform, provide insight, and address the psychophysiological needs of individuals with amputations. Art therapy was utilized in all four groups. Three of the four groups integrated guided imagery, yoga, and boxing to enhance the therapeutic experience and achieve goals. Various needs of individuals with amputations were identified through an integrative narrative review research study. A literature matrix was used for data organization, and for data categorization, a thematic analysis was used (Betts & Deaver, 2019). These proposed groups can be used to track progress within the rehabilitation setting. These groups can increase a sense of safety, feelings of control and coherent communication, emotion regulation, strength through yoga and boxing exercises, acceptance of new body/ limitations, autonomy, mastery, strength, and confidence, foster a sense of community, and allow participants to self-reflect on their amputation journey. Expressive art therapies are beneficial for individuals with limb loss and should be implemented in rehabilitation to provide a transitional object that can help ease the transition from hospital to home.
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    Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia
    (Massachusetts Medical Society, 2022-11-07) Farber, Alik; Menard, Matthew T.; Conte, Michael S.; Kaufman, John A.; Powell, Richard J.; Choudhry, Niteesh K.; Hamza, Taye H.; Assmann, Susan F.; Creager, Mark A.; Cziraky, Mark J.; Dake, Michael D.; Jaff, Michael R.; Reid, Diane; Siami, Flora S.; Sopko, George; White, Christopher J.; van Over, Max; Strong, Michael B.; Villarreal , Maria F.; McKean, Michelle; Azene, Ezana; Azarbal, Amir; Barleben, Andrew; Chew, David K.; Clavijo, Leonardo C.; Douville, Yvan; Findeiss, Laura; Garg, Nitin; Gasper, Warren; Giles, Kristina A.; Goodney, Philip P.; Hawkins, Beau M.; Herman, Christine R.; Kalish, Jeffrey A.; Koopmann, Matthew C.; Laskowski, Igor A.; Mena-Hurtado, Carlos; Motaganahalli, Raghu; Rowe, Vincent L.; Schanzer, Andres; Schneider, Peter A.; Siracuse, Jeffrey J.; Venermo, Maarit; Rosenfield, Kenneth; BEST-CLI Investigators; Surgery, School of Medicine
    BACKGROUND Patients with chronic limb-threatening ischemia (CLTI) require revascularization to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an initial strategy of endovascular therapy or surgical revascularization for CLTI is superior for improving limb outcomes. METHODS In this international, randomized trial, we enrolled 1830 patients with CLTI and infrainguinal peripheral artery disease in two parallel-cohort trials. Patients who had a single segment of great saphenous vein that could be used for surgery were assigned to cohort 1. Patients who needed an alternative bypass conduit were assigned to cohort 2. The primary outcome was a composite of a major adverse limb event — which was defined as amputation above the ankle or a major limb reintervention (a new bypass graft or graft revision, thrombectomy, or thrombolysis) — or death from any cause. RESULTS In cohort 1, after a median follow-up of 2.7 years, a primary-outcome event occurred in 302 of 709 patients (42.6%) in the surgical group and in 408 of 711 patients (57.4%) in the endovascular group (hazard ratio, 0.68; 95% confidence interval [CI], 0.59 to 0.79; P<0.001). In cohort 2, a primary-outcome event occurred in 83 of 194 patients (42.8%) in the surgical group and in 95 of 199 patients (47.7%) in the endovascular group (hazard ratio, 0.79; 95% CI, 0.58 to 1.06; P=0.12) after a median follow-up of 1.6 years. The incidence of adverse events was similar in the two groups in the two cohorts. CONCLUSIONS Among patients with CLTI who had an adequate great saphenous vein for surgical revascularization (cohort 1), the incidence of a major adverse limb event or death was significantly lower in the surgical group than in the endovascular group. Among the patients who lacked an adequate saphenous vein conduit (cohort 2), the outcomes in the two groups were similar. (Funded by the National Heart, Lung, and Blood Institute; BEST-CLI ClinicalTrials.gov number, NCT02060630.)