Browsing by Subject "alcohol preference"

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    Characterizing the roles of long non-coding RNA in rat alcohol preference
    (IEEE, 2016-12) Zhou, Ao; Wang, Yadong; Liu, Yunlong; Feng, Weixing; Edenberg, Howard J.; Medical and Molecular Genetics, School of Medicine
    Alcohol is one of the major threats to health in United States. With the emerging of next-generation sequencing technology, the association between alcohol preference and the variants and expression of genes has been investigated. However, the roles of long non-coding RNAs (lncRNA) in alcohol preference remains unclear. In this study, we identified 37 novel lncRNAs that differentially expressed across alcohol preferring (P) and non-preferring (NP) rats. The functional study on these lncRNAs demonstrates that they are associated with gene regulation, as well as neural functions. This suggests that these lncRNAs may contribute to the alcohol preference behaviors.
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    Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence
    (Wiley, 2015-01) Bell, Richard L.; Lopez, Marcelo F.; Cui, Changhai; Egli, Mark; Johnson, Kirk W.; Franklin, Kelle M.; Becker, Howard C.; Department of Psychiatry, IU School of Medicine
    Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol-preferring P rats, high-alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol-dependent mice at doses which had no effect in non-dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.