- Browse by Subject
Browsing by Subject "acetonitrile"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)–H bonds with acetonitrile(RSC, 2016-04-21) Liu, Yongbing; Yang, Ke; Ge, Haibo; Department of Chemistry & Chemical Biology, School of ScienceThe direct cyanomethylation of unactivated sp3 C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp3 C–H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.