Browsing by Subject "acetonitrile"

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    Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp3)–H bonds with acetonitrile
    (RSC, 2016-04-21) Liu, Yongbing; Yang, Ke; Ge, Haibo; Department of Chemistry & Chemical Biology, School of Science
    The direct cyanomethylation of unactivated sp3 C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp3 C–H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.