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Item A Single Histrelin Implant Is Effective for 2 Years for Treatment of Central Precocious Puberty(Elsevier, 2013) Lewis, Katherine A.; Goldyn, Andrea K.; West, Karen W.; Eugster, Erica A.; Pediatrics, School of MedicineWe investigated whether a "yearly" histrelin implant would provide pubertal suppression when left in place for 2 years. Equivalent suppression was observed when comparing 12 and 24 months in 33 children with central precocious puberty. A single implant for 2 years reduces cost and number of implant procedures.