Browsing by Subject "Transformation"

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Pieces from the heart of nature
    (2023) Niloofar, Alibakhshi; Holder, Dawn
    This paper discusses the establishment of a new connection between my internal and external world through breaking personal boundaries and transforming geometric forms in artwork. While my inner world is highly organized, my outer world appears disorderly. However, imperfection adds to the world's beauty, and the ultimate goal of this paper is to allow the audience to grasp this transformation and gain a new perspective on life through my artwork. The final form that I present remains faithful to the original forms while meeting the desired outcome of conveying the transformative power of breaking personal boundaries and embracing shortcomings in the external world. This experience brings both my audiences and me a new perspective on life. Using wood as a material in art can help bridge the gap between the internal and external worlds. The process of working with wood can be meditative and introspective, enabling the artist to connect with their inner self while creating a physical representation of their thoughts and emotions. Additionally, the idea of finding order and hope in apparent disorder can be reflected through using letters and wood as materials in art. The composition of the letters can come from an orderly mind, and by overlapping and lining up the letters, the idea is conveyed that there is still order and hope. Similarly, the natural patterns and variations in wood can represent order and beauty in the midst of chaos, making it a fitting material for art.
  • Thumbnail Image
    Item
    Progression and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma and B-cell prolymphocytic leukemia: Report from the 2021 SH/EAHP Workshop
    (Oxford University Press, 2023) Czader, Magdalena; Amador, Catalina; Cook, James R.; Thakkar, Devang; Parker, Clay; Dave, Sandeep S.; Dogan, Ahmet; Duffield, Amy S.; Nejati, Reza; Ott, German; Xiao, Wenbin; Wasik, Mariusz; Goodlad, John R.; Pathology and Laboratory Medicine, School of Medicine
    Objectives: Session 3 of the 2021 Workshop of the Society for Hematopathology/European Association for Haematopathology examined progression and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and B-cell prolymphocytic leukemia (B-PLL). Methods: Thirty-one cases were reviewed by the panel. Additional studies such as immunohistochemistry and molecular genetic testing, including whole-exome sequencing and expression profiling, were performed in select cases. Results: Session 3 included 27 CLL/SLL cases and miscellaneous associated proliferations, 3 cases of B-PLL, and 1 case of small B-cell lymphoma. The criteria for -accelerated CLL/SLL are established for lymph nodes, but extranodal disease can be diagnostically challenging. Richter transformation (RT) is a broad term and includes true transformation from original CLL/SLL clone(s) and clonally unrelated neoplasms. The morphologic, immunophenotypic, and genetic spectrum is diverse with classical and highly unusual examples. T-cell proliferations can also be encountered in CLL/SLL. B-cell prolymphocytic leukemia is a rare, diagnostically challenging disease due to its overlaps with other lymphoid neoplasms. Conclusions: The workshop highlighted complexity of progression and transformation in CLL/SLL and B-PLL, as well as diagnostic caveats accompanying heterogeneous presentations of RT and other manifestations of disease progression. Molecular genetic studies are pivotal for diagnosis and determination of clonal relationship, and to predict response to treatment and identify resistance to targeted therapy.
  • Thumbnail Image
    Item
    Progression of follicular lymphoma and related entities: Report from the 2021 SH/EAHP Workshop
    (Oxford University Press, 2023-05-11) Duffield, Amy S.; Dogan, Ahmet; Amador, Catalina; Cook, James R.; Czader, Magdalena; Goodlad, John R.; Nejati, Reza; Xiao, Wenbin; Happ, Lanie; Parker, Clay; Thacker, Elizabeth; Thakkar, Devang; Dave, Sandeep S.; Wasik, Mariusz A.; Ott, German; Pathology and Laboratory Medicine, School of Medicine
    Objectives: The 2021 Society for Hematopathology and European Association for Haematopathology Workshop addressed the molecular and cytogenetic underpinnings of transformation and transdifferentiation in lymphoid neoplasms. Methods: Session 4, "Transformations of Follicular Lymphoma," and session 5, "Transformations of Other B-Cell Lymphomas," included 45 cases. Gene alteration analysis and expression profiling were performed on cases with submitted formalin-fixed, paraffin embedded tissue. Results: The findings from session 4 suggest that "diffuse large B-cell lymphoma/high-grade B-cell lymphoma with rearrangements of MYC and BCL2" is a distinct category arising from the constraints of a preexisting BCL2 translocation. TdT expression in aggressive B-cell lymphomas is associated with MYC rearrangements, immunophenotypic immaturity, and a dismal prognosis but must be differentiated from lymphoblastic -lymphoma. Cases in session 5 illustrated unusual morphologic and immunophenotypic patterns of transformation. Additionally, the findings support the role of cytogenetic abnormalities-specifically, MYC and NOTCH1 rearrangements-as well as single gene alterations, including TP53, in transformation. Conclusions: Together, these unique cases and their accompanying molecular and cytogenetic data suggest potential mechanisms for and unusual patterns of transformation in B-cell lymphomas and indicate numerous opportunities for further study.
  • Thumbnail Image
    Item
    Unattached
    (2015) Connelly, Carly; Hull, Greg
    I am anxiously aware of human vulnerability; the brevity of living and the impermanence of the present. There is a prism of experience in the complexity of life and death through which my work is influenced. Nothing is a direct reproduction of reality but rather, a reformed, reshaped and restored version of its past. My work imitates subconscious fears, passions, and relationships with a world that provides both destruction and renewal; the dichotomy of pain and pleasure in life in many ways informs the understanding of self and identity - but it does not define it. The work blurs between reality and fantasy, exposure and repression, surface and structure, eternity and the ephemeral. I transform materials and blend processes to create mixed media sculptures and installations that respond to space, form, and compositional relationships that re-examine my own existence and serves as a self-portrait.