Browsing by Subject "Thyroid hormone replacement"

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    Takotsubo Cardiomyopathy in the Setting of Myxedema Coma
    (Springer Nature, 2022-12-05) Chan, Eric K.; Brown, Cameron; Bachar, Roudi; Smith, Antonio; Srivangipuram, Sudarsana; Medicine, School of Medicine
    Myxedema coma and its treatment are potent physical stressors that likely predispose patients to develop Takotsubo cardiomyopathy (TCM). We postulate a multifactorial pathophysiology for TCM that includes a mechanism involving catecholamine-induced potentiation of cardiac adrenoreceptors during thyroid hormone replacement in the setting of severe hypothyroidism. Furthermore, TCM can be difficult to anticipate when presenting as a complication of another diagnosis. In this case report, we aim to improve awareness of TCM as a consequence of extreme hypothyroid states.