Browsing by Subject "Thorax"

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    Exhaled breath condensate biomarkers in critically ill, mechanically ventilated patients
    (IOP, 2020-11-12) Davis, Michael D.; Winters, Brett R.; Madden, Michael C.; Pleil, Joachim D.; Sessler, Curtis N.; Wallace, M. Ariel Geer; Ward-Caviness, Cavin K.; Montpetit, Alison J.; Pediatrics, School of Medicine
    Pneumonia is a significant risk for critically ill, mechanically ventilated (CIMV) patients. Diagnosis of pneumonia generally requires a combination of clinician-guided diagnoses and clinical scoring systems. Exhaled breath condensate (EBC) can be safely collected non-invasively from CIMV patients. Hundreds of biomarkers in EBC are associated with acute disease states, including pneumonia. We evaluated cytokines in EBC from CIMV patients and hypothesized that these biomarkers would correlate with disease severity in pneumonia, sepsis, and death. EBC IL-2 levels were associated with chest radiograph severity scores (odds ratio = 1.68; 95% confidence interval = 1.09-2.60; P = 0.02). EBC TNF-α levels were also associated with pneumonia (odds ratio = 3.20; 95% confidence interval = 1.19-8.65; P = 0.02). The techniques and results from this study may be useful for all mechanically ventilated patients.
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    Parasitic lung diseases
    (European Respiratory Society, 2022-11-29) Al-Tawfiq, Jaffar A.; Kim, Hojoong; Memish, Ziad A.; Medicine, School of Medicine
    Parasitic lung diseases are caused by a number of parasites as a result of transient passage in the lung or as a result of an immunologic reaction. The clinical presentation may be in the form of focal or cystic lesions, pleural effusion or diffuse pulmonary infiltrates. With increasing globalisation, it is important to consider parasitic infections in the differential diagnosis of lung diseases. This is particularly important since early identification and prompt therapy result in full cure of these conditions. In this review, we summarise the most common parasitic lung diseases.