Browsing by Subject "Th17"

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    STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells
    (Taylor & Francis Group, 2014-10-30) Glosson-Byers, Nicole L.; Sehra, Sarita; Kaplan, Mark H.; Department of Pediatrics, School of Medicine
    STAT4 is a critical mediator of inflammatory immunity and is required for all known IL-12 biological responses, including the induction of IFN-γ and development of Th1 cells. We demonstrate that IL-23, an IL-12-related cytokine, also requires STAT4 for optimal IL-17 secretion from memory T helper cells and NKT cells. Although IL-23 stimulation had modest effects on STAT4 activation, STAT4-deficiency results in reduced Il23r expression. These data demonstrate a restricted requirement for STAT4 in innate and adaptive IL-17-secreting T cell responses that might contribute to inflammatory immunity.