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Item Interleukin-13 Is Unlucky for Allergy Sufferers(Elsevier, 2019-10) Xie, Markus M.; Dent, Alexander L.; Microbiology and Immunology, School of MedicineAnaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al . now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes high-affinity IgE responses. The discovery of T follicular helper (Tfh)13 cells defines potential new targets for allergy therapies.