Browsing by Subject "TdT"

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    Progression of follicular lymphoma and related entities: Report from the 2021 SH/EAHP Workshop
    (Oxford University Press, 2023-05-11) Duffield, Amy S.; Dogan, Ahmet; Amador, Catalina; Cook, James R.; Czader, Magdalena; Goodlad, John R.; Nejati, Reza; Xiao, Wenbin; Happ, Lanie; Parker, Clay; Thacker, Elizabeth; Thakkar, Devang; Dave, Sandeep S.; Wasik, Mariusz A.; Ott, German; Pathology and Laboratory Medicine, School of Medicine
    Objectives: The 2021 Society for Hematopathology and European Association for Haematopathology Workshop addressed the molecular and cytogenetic underpinnings of transformation and transdifferentiation in lymphoid neoplasms. Methods: Session 4, "Transformations of Follicular Lymphoma," and session 5, "Transformations of Other B-Cell Lymphomas," included 45 cases. Gene alteration analysis and expression profiling were performed on cases with submitted formalin-fixed, paraffin embedded tissue. Results: The findings from session 4 suggest that "diffuse large B-cell lymphoma/high-grade B-cell lymphoma with rearrangements of MYC and BCL2" is a distinct category arising from the constraints of a preexisting BCL2 translocation. TdT expression in aggressive B-cell lymphomas is associated with MYC rearrangements, immunophenotypic immaturity, and a dismal prognosis but must be differentiated from lymphoblastic -lymphoma. Cases in session 5 illustrated unusual morphologic and immunophenotypic patterns of transformation. Additionally, the findings support the role of cytogenetic abnormalities-specifically, MYC and NOTCH1 rearrangements-as well as single gene alterations, including TP53, in transformation. Conclusions: Together, these unique cases and their accompanying molecular and cytogenetic data suggest potential mechanisms for and unusual patterns of transformation in B-cell lymphomas and indicate numerous opportunities for further study.