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Item ACLRO: An Ontology for the Best Practice in ACLR Rehabilitation(2020-10) Phalakornkule, Kanitha; Jones, Josette F.; Boukai, Ben; Liu, Xiaowen; Purkayatha, Saptarshi; Duncan, William D.With the rise of big data and the demands for leveraging artificial intelligence (AI), healthcare requires more knowledge sharing that offers machine-readable semantic formalization. Even though some applications allow shared data interoperability, they still lack formal machine-readable semantics in ICD9/10 and LOINC. With ontology, the further ability to represent the shared conceptualizations is possible, similar to SNOMED-CT. Nevertheless, SNOMED-CT mainly focuses on electronic health record (EHR) documenting and evidence-based practice. Moreover, due to its independence on data quality, the ontology enhances advanced AI technologies, such as machine learning (ML), by providing a reusable knowledge framework. Developing a machine-readable and sharable semantic knowledge model incorporating external evidence and individual practice’s values will create a new revolution for best practice medicine. The purpose of this research is to implement a sharable ontology for the best practice in healthcare, with anterior cruciate ligament reconstruction (ACLR) as a case study. The ontology represents knowledge derived from both evidence-based practice (EBP) and practice-based evidence (PBE). First, the study presents how the domain-specific knowledge model is built using a combination of Toronto Virtual Enterprise (TOVE) and a bottom-up approach. Then, I propose a top-down approach using Open Biological and Biomedical Ontology (OBO) Foundry ontologies that adheres to the Basic Formal Ontology (BFO)’s framework. In this step, the EBP, PBE, and statistic ontologies are developed independently. Next, the study integrates these individual ontologies into the final ACLR Ontology (ACLRO) as a more meaningful model that endorses the reusability and the ease of the model-expansion process since the classes can grow independently from one another. Finally, the study employs a use case and DL queries for model validation. The study's innovation is to present the ontology implementation for best-practice medicine and demonstrate how it can be applied to a real-world setup with semantic information. The ACLRO simultaneously emphasizes knowledge representation in health-intervention, statistics, research design, and external research evidence, while constructing the classes of data-driven and patient-focus processes that allow knowledge sharing explicit of technology. Additionally, the model synthesizes multiple related ontologies, which leads to the successful application of best-practice medicine.Item Amplified fragment length polymorphism analysis supports the valid separate species status of Lucilia caesar and L. illustris (Diptera: Calliphoridae)(Taylor & Francis:, 2017-12-08) Picard, Christine J.; Wells, Jeffrey D.; Ullyot, Anne; Rognes, Knut; Biology, School of ScienceCommon DNA-based species determination methods fail to distinguish some blow flies in the forensically and medically important genus Lucilia Robineau-Desvoidy. This is a practical problem, and it has also been interpreted as casting doubt on the validity of some morphologically defined species. An example is Lucilia illustris and L. caesar, which co-occur in Europe whilst only L. illustris has been collected in North America. Reports that these species shared both mitochondrial and nuclear gene sequences, along with claims that diagnostic morphological characters are difficult to interpret, were used to question their separate species status. We report here that amplified fragment length polymorphism profiles strongly support the validity of both species based on both assignment and phylogenetic analysis, and that traditional identification criteria based on male and female genital morphology are more reliable than has been claimed.Item Cladistic Analysis of the Paleozoic Bryozoan Families Monticuliporidae and Mesotrypidae(2011-03-16) Adamczyk, Amber Diane; Pachut, Joseph F., 1950-; Tedesco, Lenore P.; Rosenberg, Gary D.Two closely related families of Ordovician bryozoans, the Monticuliporidae and the Mesotrypidae, collectively contain 12 genera that have been reclassified repeatedly by various authors. Using published illustrations for the type specimens of each genus, character states for 267 morphological attributes were coded. Cladistic results were compared between the programs PAST and PAUP, and contrasted with phenetic methods. PAUP produced the shortest trees, with better summary index values and low homoplasy. Phenetic results varied, depending largely on the similarity measures used. Cladistic analysis produced five tree topologies, the most parsimonious of which consisted of a monophyletic crown group, representing Family Monticuliporidae, and a paraphyletic stem group that included the genera Mesotrypa and Diazipora. The crown group includes the genera Aspidopora, Atactoporella, Acantholaminatus, Peronopora, Homotrypella, Homotrypa, Gortanipora, Monticulipora, Prasopora, and Prasoporina. The paraphyletic stem group matches Astrova’s concept of Family Mesotrypidae. These results suggest the placement of all 12 genera in a single Family Monticuliporidae. Future studies that include data for additional closely related genera in might provide a clearer picture of familial assignments for these, and other, stenolaemate genera.Item The impact of supply chain integration on performance: A contingency and configuration approach(2010) Flynn, Barbara B.; Huo, Baofeng; Zhao, XiandeThis study extends the developing body of literature on supply chain integration (SCI), which is the degree to which a manufacturer strategically collaborates with its supply chain partners and collaboratively manages intra- and inter-organizational processes, in order to achieve effective and efficient flows of products and services, information, money and decisions, to provide maximum value to the customer. The previous research is inconsistent in its findings about the relationship between SCI and performance. We attribute this inconsistency to incomplete definitions of SCI, in particular, the tendency to focus on customer and supplier integration only, excluding the important central link of internal integration. We study the relationship between three dimensions of SCI, operational and business performance, from both a contingency and a configuration perspective. In applying the contingency approach, hierarchical regression was used to determine the impact of individual SCI dimensions (customer, supplier and internal integration) and their interactions on performance. In the configuration approach, cluster analysis was used to develop patterns of SCI, which were analyzed in terms of SCI strength and balance. Analysis of variance was used to examine the relationship between SCI pattern and performance. The findings of both the contingency and configuration approach indicated that SCI was related to both operational and business performance. Furthermore, the results indicated that internal and customer integration were more strongly related to improving performance than supplier integration.Item IUPUI Taxonomy for Service Learning Courses(2016-08-16) Hahn, Thomas; Hatcher, Julie; Price, Mary F.; Studer, MorganThe Center for Service and Learning at Indiana University-Purdue University, Indianapolis has developed a Taxonomy of service learning courses that supports fidelity and quality by identifying six crucial attributes of service learning courses (i.e., diversity of interactions, civic competencies, community activities, critical reflection, reciprocal partnerships, and assessment).Item Project-Based Learning: IUPUI High-Impact Taxonomy(2023-04-27) Oesch-Minor, Deborah; Pierce, David; Hayes, Kelly; Mihci, Gurkan; Robertson, Nancy Marie; Stucky, Tom; Van Busum, Kelly; Westerhaus-Renfro, CharlotteProject-Based Learning [PBL] infuses content-rich readings, lectures, and instruction to support students as they learn by actively engaging in real-world and personally meaningful projects. PBL is a high-impact practice (HIP) that can be applied simultaneously when using other HIPS or pedagogical approaches (e.g., case study, capstone, research, study abroad, work-integrated learning, community-based learning, writing intensive course, ePortfolio). In PBL courses students identify real-world/authentic problems to explore and participate in sustained inquiry throughout the project. Students do not re-ceive information to memorize it; they learn because they have a real need to know something so they can use it to solve a problem or answer a question that matters to them. Students go through iterative cycles of posing real questions, finding resources, collecting data, interpreting information, and reporting findings. Student progress is supported through scaffolded activities, feedback loops with peers and faculty, and meeting benchmarks for progress. At key moments, students reflect on the process, what they have achieved, and make connections between the work they are completing and relevant course concepts.Item Taxonomic Changes for Human Viruses, 2020 to 2022(American Society for Microbiology, 2023) Relich, Ryan F.; Loeffelholz, Michael J.; Pathology and Laboratory Medicine, School of MedicineThe classification of viruses remains relevant to several disciplines, including clinical virology. Since the original publication of this review in 2019, many known viruses have undergone taxonomic revisions, and several novel human and animal viruses have been described. Here, we provide an update to our previous reviews of taxonomic changes for disease-causing viruses of humans, covering changes that occurred between 2020 and 2022. As with previous editions, this update was informed by recent advances in virus taxonomy made by the International Committee on Taxonomy of Viruses; the changes and additions noted herein are not all-inclusive.