Browsing by Subject "Symptom severity"

Now showing 1 - 3 of 3
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    Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma
    (Research Square, 2024-03-08) Sendi, Mohammad; Fu, Zening; Harnett, Nathaniel; van Rooij, Sanne; Vergara, Victor; Pizzagalli, Diego; Daskalakis, Nikolaos; House, Stacey; Beaudoin, Francesca; An, Xinming; Neylan, Thomas; Clifford, Gari; Jovanovic, Tanja; Linnstaedt, Sarah; Germine, Laura; Bollen, Kenneth; Rauch, Scott; Haran, John; Storrow, Alan; Lewandowski, Christopher; Musey, Paul, Jr.; Hendry, Phyllis; Sheikh, Sophia; Jones, Christopher; Punches, Brittany; Swor, Robert; Gentile, Nina; Murty, Vishnu; Hudak, Lauren; Pascual, Jose; Seamon, Mark; Harris, Erica; Chang, Anna; Pearson, Claire; Peak, David; Merchant, Roland; Domeier, Robert; Rathlev, Niels; O'Neil, Brian; Sergot, Paulina; Sanchez, Leon; Bruce, Steven; Sheridan, John; Harte, Steven; Kessler, Ronald; Koenen, Karestan; McLean, Samuel; Stevens, Jennifer; Calhoun, Vince; Ressler, Kerry; Emergency Medicine, School of Medicine
    This study examines the association between brain dynamic functional network connectivity (dFNC) and current/future posttraumatic stress (PTS) symptom severity, and the impact of sex on this relationship. By analyzing 275 participants' dFNC data obtained ~2 weeks after trauma exposure, we noted that brain dynamics of an inter-network brain state link negatively with current (r=-0.179, pcorrected= 0.021) and future (r=-0.166, pcorrected= 0.029) PTS symptom severity. Also, dynamics of an intra-network brain state correlated with future symptom intensity (r = 0.192, pcorrected = 0.021). We additionally observed that the association between the network dynamics of the inter-network brain state with symptom severity is more pronounced in females (r=-0.244, pcorrected = 0.014). Our findings highlight a potential link between brain network dynamics in the aftermath of trauma with current and future PTSD outcomes, with a stronger protective effect of inter-network brain states against symptom severity in females, underscoring the importance of sex differences.
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    Measurement of Patients' Acceptable Symptom Levels and Priorities for Symptom Improvement in Advanced Prostate Cancer
    (Research Square, 2024-09-18) Snyder, Stella; Secinti, Ekin; Krueger, Ellen; Adra, Nabil; Pili, Roberto; Hanna, Nasser; Mosher, Catherine; Psychology, School of Science
    Purpose: Limited research has evaluated the success criteria and priorities for symptom improvement of patients with cancer to inform patient-centered care. In this study, we adapted and tested a measure of these constructs, the Patient-Centered Outcomes Questionnaire (PCOQ), for patients with advanced prostate cancer. We compared acceptable symptom severity levels following symptom treatment across 10 symptoms and identified patient subgroups based on symptom importance. Methods: Patients with advanced prostate cancer (N = 99) participated in a one-time survey, which included a modified version of the PCOQ, standard symptom measures, and additional clinical characteristics. Results: The modified PCOQ demonstrated construct validity through its correlations with related theoretical constructs. There was a moderate correlation between symptom severity and importance. Acceptable symptom severity levels were generally low, with sexual dysfunction having a higher acceptable severity than most other symptoms. Three patient subgroups were identified: (1) those who rated all symptoms as low in importance (n = 43); (2) those who rated all symptoms as moderately important (n = 33); and (3) those who rated all symptoms as highly important (n= 18). Subgroups were associated with functional status, fatigue, sleep problems, pain, and emotional distress. Conclusion: The modified PCOQ demonstrated preliminary evidence of construct validity. Patients generally considered low symptom severity to be acceptable, with variations across symptoms. Results suggest that symptom severity and importance are related but distinct aspects of the symptom experience in advanced prostate cancer. Patients' diverse priorities for symptom improvement point to the need for individualized treatment plans.
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    Measurement of Patients’ Acceptable Symptom Levels and Priorities for Symptom Improvement in Advanced Lung Cancer
    (Springer, 2021) Krueger, Ellen; Secinti, Ekin; Wu, Wei; Hanna, Nasser; Durm, Gregory; Einhorn, Lawrence; Jalal, Shadia; Mosher, Catherine E.; Psychiatry, School of Medicine
    Purpose: Little research has assessed cancer patients' success criteria and priorities for symptom improvement to inform patient-centered care. Thus, we modified and tested a measure of these constructs for advanced lung cancer patients. We compared acceptable severity levels following symptom treatment across eight symptoms and identified patient subgroups based on symptom importance. Methods: Advanced lung cancer patients (N=102) completed a one-time survey, including the modified Patient-Centered Outcomes Questionnaire (PCOQ), standard symptom measures, and other clinical characteristics. Results: The modified PCOQ showed evidence of construct validity through associations with theoretically related constructs. Symptom severity and importance were moderately correlated. Levels of acceptable symptom severity were low and did not differ across the eight symptoms. Four patient subgroups were identified: (1) those who rated all symptoms as low in importance (n=12); (2) those who rated bronchial symptoms and sleep problems as low in importance and all other symptoms as moderately important (n=29); (3) those who rated nausea and emotional distress as low in importance and all other symptoms as moderately important (n=23); and (4) those who rated all symptoms as highly important (n=33). Subgroups were unrelated to clinical characteristics, except for functional status. Conclusion: The modified PCOQ showed evidence of construct validity. Patients considered low symptom severity to be acceptable, irrespective of the symptom. Findings suggest that symptom severity and importance are related yet distinct aspects of the advanced lung cancer symptom experience. Patients have heterogeneous priorities for symptom improvement, which has implications for tailoring treatment.