Browsing by Subject "Stem cell therapy"

Now showing 1 - 3 of 3
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    Commentary: Another iteration of cell-based therapy for acute ischemia-reperfusion injury, this time in the spine
    (Elsevier, 2021-07-02) Herrmann, Jeremy L.; Surgery, School of Medicine
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    Stem cell derived therapies to preserve and repair the developing intestine
    (Elsevier, 2023) Mesfin, Fikir M.; Manohar, Krishna; Hunter, Chelsea E.; Shelley, W. Christopher; Brokaw, John P.; Liu, Jianyun; Ma, Minglin; Markel, Troy A.; Surgery, School of Medicine
    Stem cell research and the use of stem cells in therapy have seen tremendous growth in the last two decades. Neonatal intestinal disorders such as necrotizing enterocolitis, Hirschsprung disease, and gastroschisis have high morbidity and mortality and limited treatment options with varying success rates. Stem cells have been used in several pre-clinical studies to address various neonatal disorders with promising results. Stem cell and patient population selection, timing of therapy, as well as safety and quality control are some of the challenges that must be addressed prior to the widespread clinical application of stem cells. Further research and technological advances such as the use of cell delivery technology can address these challenges and allow for continued progress towards clinical translation.
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    Stem cell therapy in necrotizing enterocolitis: Current state and future directions
    (Elsevier, 2018-02) Drucker, Natalie A.; McCulloh, Christopher J.; Li, Bo; Pierro, Agostino; Besner, Gail E.; Markel, Troy A.; Surgery, School of Medicine
    Stem cell therapy is a promising treatment modality for necrotizing enterocolitis. Among the many promising stem cells identified to date, it is likely that mesenchymal stem cells will be the most useful and practical cell-based therapies for this condition. Using acellular components such as exosomes or other paracrine mediators are promising as well. Multiple mechanisms are likely at play in the positive effects provided by these cells, and further research is underway to further elucidate these effects.