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Item Memory concerns in the early Alzheimer’s disease prodrome: Regional association with tau deposition(Elsevier, 2018-03-24) Swinford, Cecily G.; Risacher, Shannon L.; Charil, Arnaud; Schwarz, Adam J.; Saykin, Andrew J.; Alzheimer’s Disease Neuroimaging Initiative; Radiology and Imaging Sciences, School of MedicineIntroduction: Relationship between self- and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD). Methods: Regional mean standardized uptake value ratios were extracted from [18F]flortaucipir positron emission tomography (PET) scans of 82 at-risk adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Associations between self- and informant ECog memory scores and tau aggregation were analyzed on both regional and voxelwise bases. Analyses were completed both on the whole sample and restricted to amyloid-positive individuals only. Results: Memory concerns were associated with tau aggregation. Self-perception was more associated with frontal tau. In contrast, informant scores were more associated with parietal tau. This source-by-region interaction was more prominent in amyloid-positive participants and observed in both regional and voxelwise analyses. Discussion: Quantitative assessment of perceived memory functioning may be useful for screening older adults at risk for Alzheimer's disease. Individuals and their informants may provide complementary information relating to the anatomical distribution of tau.Item Threshold of vapour–pressure deficit constraint on light use efficiency varied with soil water content(Wiley, 2022-07) Gao, Dexin; Wang, Shuai; Li, Zidong; Wei, Fangli; Chen, Peng; Song, Shuang; Wang, Yaping; Wang, Lixin; Fu, Bojie; Earth Sciences, School of ScienceUnderstanding the constraints on light-use efficiency (LUE) induced by high evaporative water demand (vapour–pressure deficit; VPD) and soil water stress (soil moisture content; SMC) is crucial for understanding and simulating vegetation productivity, particularly in the arid and semi-arid regions. However, the relative impacts of VPD and SMC on LUE are unclear, as we lack a mechanistic understanding of impacts and their interactions. In this study, we quantified the relative roles of VPD and SMC in limiting LUE and analysed the interactions among VPD, SMC and LUE using data from CO2 and water flux stations and weather stations along a climatic gradient in the Heihe River Basin, China. We found a threshold of VPD constraint on LUE; above the threshold, LUE decreased at only 3.6% to 23.1% of the rate below the threshold. As SMC decreased, however, the VPD threshold increased, and the reduction of LUE caused by VPD decreased significantly, which is more than half of that in moister regions. Therefore, both VPD and SMC played essential roles in LUE limitation caused by water stress. A threshold also existed for heat flux and the correlation between SMC and LUE; the strength of the correlation first decreased and then increased with increasing VPD. Our results clarified the relative impacts of VPD and SMC on LUE, and can improve simulation and prediction of plant productivity.