Browsing by Subject "Robust estimation"

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    Robust estimation of heterogeneous treatment effects: an algorithm-based approach
    (Taylor & Francis, 2021) Li, Ruohong; Wang, Honglang; Zhao, Yi; Su, Jing; Tu, Wanzhu; Biostatistics, School of Public Health
    Heterogeneous treatment effect estimation is an essential element in the practice of tailoring treatment to suit the characteristics of individual patients. Most existing methods are not sufficiently robust against data irregularities. To enhance the robustness of the existing methods, we recently put forward a general estimating equation that unifies many existing learners. But the performance of model-based learners depends heavily on the correctness of the underlying treatment effect model. This paper addresses this vulnerability by converting the treatment effect estimation to a weighted supervised learning problem. We combine the general estimating equation with supervised learning algorithms, such as the gradient boosting machine, random forest, and artificial neural network, with appropriate modifications. This extension retains the estimators’ robustness while enhancing their flexibility and scalability. Simulation shows that the algorithm-based estimation methods outperform their model-based counterparts in the presence of nonlinearity and non-additivity. We developed an R package, RCATE, for public access to the proposed methods. To illustrate the methods, we present a real data example to compare the blood pressure-lowering effects of two classes of antihypertensive agents.
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    Robust Inference for Heterogeneous Treatment Effects With Applications to NHANES Data
    (2024-12) Mo, Ran; Wang, Honglang; Li, Fang; Tan, Fei; Peng, Hanxiang
    Estimating the conditional average treatment effect (CATE) using data from the National Health and Nutrition Examination Survey (NHANES) provides valuable insights into the heterogeneous impacts of health interventions across diverse populations, facilitating public health strategies that consider individual differences in health behaviors and conditions. However, estimating CATE with NHANES data face challenges often encountered in observational studies, such as outliers, heavy-tailed error distributions, skewed data, model misspecification, and the curse of dimensionality. To address these challenges, this dissertation presents three consecutive studies that thoroughly explore robust methods for estimating heterogeneous treatment effects. The first study introduces an outlier-resistant estimation method by incorporating M-estimation, replacing the \(L_2\) loss in the traditional inverse propensity weighting (IPW) method with a robust loss function. To assess the robustness of our approach, we investigate its influence function and breakdown point. Additionally, we derive the asymptotic properties of the proposed estimator, enabling valid inference for the proposed outlier-resistant estimator of CATE. The method proposed in the first study relies on a symmetric assumption which is commonly required by standard outlier-resistant methods. To remove this assumption while maintaining unbiasedness, the second study employs the adaptive Huber loss, which dynamically adjusts the robustification parameter based on the sample size to achieve optimal tradeoff between bias and robustness. The robustification parameter is explicitly derived from theoretical results, making it unnecessary to rely on time-consuming data-driven methods for its selection. We also derive concentration and Berry-Esseen inequalities to precisely quantify the convergence rates as well as finite sample performance. In both previous studies, the propensity scores were estimated parametrically, which is sensitive to model misspecification issues. The third study extends the robust estimator from our first project by plugging in a kernel-based nonparametric estimation of the propensity score with sufficient dimension reduction (SDR). Specifically, we adopt a robust minimum average variance estimation (rMAVE) for the central mean space under the potential outcome framework. Together with higher-order kernels, the resulting CATE estimation gains enhanced efficiency. In all three studies, the theoretical results are derived, and confidence intervals are constructed for inference based on these findings. The properties of the proposed estimators are verified through extensive simulations. Additionally, applying these methods to NHANES data validates the estimators' ability to handle diverse and contaminated datasets, further demonstrating their effectiveness in real-world scenarios.