Browsing by Subject "Research"

Now showing 1 - 10 of 90
  • Thumbnail Image
    Item
    The 2010 Nonprofit Fundraising Survey: Funds Raised in 2010 Compared with 2009
    (2011-03) Association of Fundraising Professionals; Blackbaud; IU Lilly Family School of Philanthropy; Guidestar; National Center for Charitable Statistics; Foundation Center
  • Thumbnail Image
    Item
    Adaptability in Medical Education: 2nd Annual Indiana University School of Medicine Education Day Program
    (IUSM, 2021-04-22) Kochhar, Komal
    Program for the 5th annual Indiana University School of Medicine Education Day held virtually on April 22, 2021. An inherent challenge of operating a large multi-campus educational system is being able to provide professional development opportunities for all our medical educators across the state. To address this need, we implemented an annual “Education Day” at Indiana University School of Medicine to promote educational scholarship across our nine-campus system. Held each spring, Education Day showcased the educational scholarship of our faculty, staff, and learners, and provided a forum to share best educational practices and forge new collaborations in educational research.
  • Thumbnail Image
    Item
    Advancing Research on the Complex Interrelations between Atrial fibrillation and Heart Failure: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop
    (American Heart Association, 2020-06-09) Al-Khatib, Sana M.; Benjamin, Emelia J.; Albert, Christine M.; Alonso, Alvaro; Chauhan, Cynthia; Chen, Peng-Sheng; Curtis, Anne B.; Desvigne-Nickens, Patrice; Ho, Jennifer E.; Lam, Carolyn S.P.; Link, Mark S.; Patton, Kristen K.; Redfield, Margaret M.; Rienstra, Michiel; Rosenberg, Yves; Schnabel, Renate; Spertus, John A.; Warner Stevenson, Lynne; Hills, Mellanie True; Voors, Adriaan A.; Cooper, Lawton S.; Go, Alan S.; Medicine, School of Medicine
    The interrelationships between atrial fibrillation (AF) and heart failure (HF) are complex and poorly understood, yet the number of patients with AF and HF continues to increase worldwide. Thus, there is a need for initiatives that prioritize research on the intersection between AF and HF. This report summarizes the proceedings of a virtual workshop convened by the National Heart, Lung, and Blood Institute to identify important research opportunities in AF and HF. Key knowledge gaps were reviewed and research priorities were proposed for characterizing the pathophysiological overlap and deleterious interactions between AF and HF; preventing HF in persons with AF; preventing AF in individuals with HF; and addressing symptom burden and health status outcomes in AF and HF. These research priorities will hopefully help inform, encourage, and stimulate innovative, cost-efficient, and transformative studies to enhance the outcomes of patients with AF and HF.
  • Thumbnail Image
    Item
    Angela Seaworth
    (2005) Seaworth, Angela
  • Thumbnail Image
    Item
  • Thumbnail Image
    Item
    Are Surgeons Behind the Scientific Eight Ball: Delayed Acquisition of the NIH K08 Mentored Career Development Award
    (Elsevier, 2020-02) Hosfield, Brian D.; John, Quincy E.; Seiler, Kristen M.; Good, Misty; Dunnington, Gary L.; Markel, Troy A.; Surgery, School of Medicine
    Background: Surgery residents complete their research training early in residency. Non-surgical trainees typically have research incorporated toward the last two years of their fellowship, conferring an advantage to apply for grants with recent research experience and preliminary data. Methods: The NIH RePORTER database was queried for K08 awardees trained in medicine, pediatrics, and surgery from 2013 to 2017. 406 K08 recipients were identified and time from completion of clinical training to achieving a K08 award was measured. Data were compared using ANOVA and expressed as mean. P < 0.05 was considered significant. Results: Surgeons took longer to obtain a K08 than those trained in internal medicine (surgery = 3.7 years, internal medicine = 2.58 years p < 0.0001)). All K08 recipients without a PhD took longer to obtain a K08 than recipients with a PhD (MD = 3.50 years and MD/PhD = 2.42 years (p=<0.0001). Conclusions: Surgeons take longer to achieve a K08 award than clinicians trained in internal medicine, possibly due to an inherent disadvantage in training structure.
  • Thumbnail Image
    Item
    Beyond Anecdote: Challenges in Bringing Rigor to Service-Learning Research
    (11/13/2005) Gelmon, Sherril; Furco, Andrew; Holland, Barbara; Bringle, Robert G.
    This conference presentation discusses the challenges of bringing rigor to service and learning research.
  • Thumbnail Image
    Item
    Biosimilars—Emerging Role in Nephrology
    (American Society of Nephrology, 2019-09-01) Wish, Jay B.; Medicine, School of Medicine
    The Food and Drug Administration (FDA) defines a “biosimilar” agent as a biologic that is highly similar to the reference or originator biologic product notwithstanding minor differences in clinically inactive components with no clinically meaningful differences in terms of the safety, purity, and potency. The advantage of biosimilars is that they are usually about 15%–30% less expensive than the reference product, which results in system-wide cost savings and increased patient access. Because biologic drugs are produced by living organisms, they are by nature heterogeneous and identical copies cannot be made, unlike generic versions of small-molecule drugs. Proposed biosimilars must undergo a rigorous evaluation process to demonstrate a high degree of structural and functional similarity with the reference biologic. Once that is confirmed, a stepwise process of comparison with the reference agent with regard to animal trials, pharmacokinetics/pharmacodynamics, immunogenicity, and human efficacy/safety is conducted. The experience with biosimilars in other highly regulated markets where patent protection for originator biologics is not as robust as in the United States has been favorable in terms of safety, efficacy, and cost savings. An FDA approval pathway was created in 2009 to expedite the approval of biosimilars; as of early 2018 nine agents had been approved through that pathway, none in nephrology. The first United States biosimilar epoetin was approved on May 15, 2018, but does not have an interchangeability designation, meaning that prescribers must specifically write for the biosimilar product for patients to receive it. Given the unfamiliarity of biosimilars within the nephrology community it is recommended that educational programs be developed to address this unmet need and for research to be conducted addressing the perceptual, clinical, and economic effect of biosimilars on our patients.
  • Thumbnail Image
    Item
    Brittany Miller
    (2010) Miller, Brittany
  • Thumbnail Image
    Item
    Caregiver Perspectives on Patient Participation in Biological Pediatric Cancer Research
    (MDPI, 2022-06-16) Kendel, Nicole E.; Belsky, Jennifer A.; Stanek, Joseph R.; Streby, Keri A.; Shah, Nilay; Pediatrics, School of Medicine
    Adolescent cancer patients and their caregivers have demonstrated willingness to participate in invasive biological sampling, either for their own potential benefit or for research purposes. However, many malignancies occur primarily in prepubescent patients and there are no similar studies in this population. Our study objective was to assess the willingness of caregivers to consent to research studies involving invasive biological sampling in children ≤ 13 years of age. Participants completed a survey assessing their willingness to allow various procedures both with and without clinical benefit to their children. Most respondents were willing to allow additional blood draws regardless of potential benefit to their children (95.6% were willing when there would be benefits and 95.6% were willing when there would not). Although the overall willingness was lower with other hypothetical procedures, the majority of respondents were still willing to allow additional biopsies for research purposes. Caregivers of young children with cancer will allow their children to undergo additional invasive procedures for research purposes. This willingness decreased with more invasive procedures without potential direct benefit, but interest remained in more than half of participants. Caregivers for young patients with cancer should be approached for participation in future biological/correlative studies.