Browsing by Subject "Rejuvenation"

Now showing 1 - 2 of 2
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    Fibroblast Senescence and Squamous Cell Carcinoma: How wounding therapies could be protective
    (Wolters Kluwer, 2013) Travers, Jeffrey B.; Spandau, Dan F.; Lewis, Davina A.; Machado, Christiane; Kingsley, Melanie; Mousdicas, Nico; Somani, Ally-Khan; Dermatology, School of Medicine
    Background: Squamous cell carcinoma (SCC), which has one of the highest incidences of all cancers in the United States, is an age-dependent disease, with the majority of these cancers diagnosed in people age 70 and older. Recent findings have led to a new hypothesis on the pathogenesis of SCC. Objectives: To evaluate the potential of preventive therapies to reduce the incidence of SCC in at-risk geriatric patients. Materials and methods: Survey of current literature on wounding therapies to prevent SCCs. Results: This new hypothesis of SCC photocarcinogenesis states that senescent fibroblasts accumulate in the dermis, resulting in a reduction in dermal insulin-like growth factor-1 (IGF-1) expression. This lack of IGF-1 expression sensitizes epidermal keratinocytes to fail to suppress ultraviolet light B (UVB)-induced mutations, leading to increased proclivity to photocarcinogenesis. Recent evidence suggests that dermal wounding therapies, specifically dermabrasion and fractionated laser resurfacing, can decrease the proportion of senescent dermal fibroblasts, increase dermal IGF-1 expression, and correct the inappropriate UVB response found in geriatric skin, protecting geriatric keratinocytes from UVB-induced SCC initiation. Conclusions: In this review, we will discuss the translation of pioneering basic science results implicating commonly used dermal fibroblast rejuvenation procedures as preventative treatments for SCC.
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    Skin resurfacing procedures: new and emerging options
    (Dove Press, 2014-08-28) Loesch, Mathew M.; Somani, Ally-Khan; Kingsley, Melanie M.; Travers, Jeffrey B.; Spandau, Dan F.; Dermatology, School of Medicine
    The demand for skin resurfacing and rejuvenating procedures has progressively increased in the last decade and has sparked several advances within the skin resurfacing field that promote faster healing while minimizing downtime and side effects for patients. Several technological and procedural skin resurfacing developments are being integrated into clinical practices today allowing clinicians to treat a broader range of patients’ skin types and pathologies than in years past, with noteworthy outcomes. This article will discuss some emerging and developing resurfacing therapies and treatments that are present today and soon to be available.