Browsing by Subject "ROP therapy"

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    Promoting vascular repair in the retina: can stem/progenitor cells help?
    (Dovepress, 2016-05-26) Phuong Trinh, Thao Le; Calzi, Sergio Li; Shaw, Lynn C.; Yoder, Mervin C.; Grant, Maria B.; Biochemistry and Molecular Biology, School of Medicine
    Since its first epidemic in the 1940s, retinopathy of prematurity (ROP) has been a challenging illness in neonatology. Higher than physiological oxygen levels impede the development of the immature retinal neuropil and vasculature. Current treatment regimens include cryotherapy, laser photocoagulation, and anti-VEGF agents. Unfortunately, none of these approaches can rescue the normal retinal vasculature, and each has significant safety concerns. The limitations of these approaches have led to new efforts to understand the pathological characteristics in each phase of ROP and to find a safer and more effective therapeutic approach. In the era of stem cell biology and with the need for new treatments for ROP, this review discusses the possible future use of unique populations of proangiogenic cells for therapeutic revascularization of the preterm retina.
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    Promoting vascular repair in the retina: can stem/progenitor cells help?
    (Dove, 2016) Trinh, Thao Le Phuong; Calzi, Sergio Li; Shaw, Lynn C.; Yoder, Mervin C.; Grant, Maria B.; Department of Ophthalmology, IU School of Medicine
    Since its first epidemic in the 1940s, retinopathy of prematurity (ROP) has been a challenging illness in neonatology. Higher than physiological oxygen levels impede the development of the immature retinal neuropil and vasculature. Current treatment regimens include cryotherapy, laser photocoagulation, and anti-VEGF agents. Unfortunately, none of these approaches can rescue the normal retinal vasculature, and each has significant safety concerns. The limitations of these approaches have led to new efforts to understand the pathological characteristics in each phase of ROP and to find a safer and more effective therapeutic approach. In the era of stem cell biology and with the need for new treatments for ROP, this review discusses the possible future use of unique populations of proangiogenic cells for therapeutic revascularization of the preterm retina.